Results 51 to 60 of about 26,177 (206)

Safety considerations of gene‐based therapies for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Gene‐based therapies show increasing promise for the treatment of neurologic disease. In 2016, nusinersen, an RNA‐based therapy, was approved for children with spinal muscular atrophy (SMA). Over 200 clinical trials have utilized gene therapy approaches for a host of neurodegenerative and neuromuscular disorders, including Alzheimer's disease (
Elizabeth A. Bevins, Gabriel C. Léger, Michelle A. Herman, John M. Ringman, Subhojit Roy, Matthew Shtrahman, Judy Pa, Howard H. Feldman   +7 more
wiley   +1 more source

Lyme borreliosis: Europe-wide coordinated surveillance and action needed?

, 2006
Lyme borreliosis (Lyme disease) is an infection caused by the spirochete bacteria Borrelia ...
R. Smith, Collective Editorial team, J Takkinen   +2 more
core   +1 more source

Hamster and Murine Models of Severe Destructive Lyme Arthritis

Clinical and Developmental Immunology, 2012
Arthritis is a frequent complication of infection in humans with Borrelia burgdorferi. Weeks to months following the onset of Lyme borreliosis, a histopathological reaction characteristic of synovitis including bone, joint, muscle, or tendon pain may ...
Erik Munson, Dean T. Nardelli, Brian K. Du Chateau, Steven M. Callister, Ronald F. Schell   +4 more
doaj   +1 more source

The history of the discovery and research of Lyme borreliosis in animals and humans

Ukrainian Journal of Veterinary Sciences, 2022
The relevance of this study is conditioned upon the substantial importance of the history of the discovery and research of Lyme borreliosis for medical science and veterinary medicine, since new theories, experiments, conclusions are built on the ...
Nataliia Soroka, Oksana Kravchuk, Olena Zhurenko   +2 more
doaj   +1 more source

Mapping Zoonotic Risk With a Biogeographic Perspective on Transmission Cycles

Journal of Biogeography, Volume 53, Issue 7, July 2026.
ABSTRACT Aim When mapping the transmission risk of zoonotic diseases, the way vectors and wild carrier hosts are integrated into the modelling process has relevant impacts on the final output. The wide diversity of zoonotic cycles entails that a single methodological approach may be insufficient to cover the influence of vectors and wild carrier hosts ...
Jesús Olivero, Marina Cobos‐Mayo, Alisa Aliaga‐Samanez   +2 more
wiley   +1 more source

Risk Factors for Tick‐Borne Diseases in Germany: A Scoping Review

Zoonoses and Public Health, Volume 73, Issue 4, Page 297-313, June 2026.
ABSTRACT Tick‐borne diseases (TBDs) have proliferated in Germany. The two most prevalent TBDs, Lyme‐borreliosis and tick‐borne encephalitis, can present with nonspecific symptoms and lead to serious neurological complications. To date, a review synthesising the risk factors of acquiring a TBD in Germany is missing.
Carolin Schlupp, Matthias Hans Belau
wiley   +1 more source

Current guidelines for the management of Lyme borreliosis in European countries

Journal of Education, Health and Sport
Introduction and purpose: Lyme borreliosis, caused by Borrelia burgdorferi sensu lato complex, is the most common vector-borne disease in Europe. Transmitted by Ixodes ticks, its prevalence is increasing due to climate change, expanded tick habitats,
Zuzanna Wyleciał, Julia Ząber, Wiktoria Zamachowska   +2 more
doaj   +1 more source

Case of Lyme borreliosis in a child

Aktualʹnaâ Infektologiâ, 2019
Lyme borreliosis (synonym: Lyme disease) is an infectious transmissible natural focal disease, the causative agents of which are spirochetes, and carriers — ixodid ticks. The first cases of Lyme borreliosis in Ukraine are known since 1994.
T.M. Kosovska, V.O. Kosovska
doaj   +1 more source

Lyme borreliosis diagnosis: state of the art of improvements and innovations

BMC Microbiology, 2023
With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world.
Mickaël Guérin, Marc Shawky, Ahed Zedan, Stéphane Octave, Bérangère Avalle, Irene Maffucci, Séverine Padiolleau-Lefèvre   +6 more
doaj   +1 more source

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten   +2 more
wiley   +1 more source