Results 61 to 70 of about 32,998 (233)

Lyme disease vaccine [PDF]

Paediatrics & Child Health, 2000
Lyme disease is the most common tick-borne infection in the United States, with more than 12,000 cases reported annually (1). The disease is characterized by a rash (erythema migrans) and various systemic (nervous, cardiac and musculoskeletal) manifestations; clinical manifestations of Lyme disease were reviewed recently (2). Most cases of Lyme disease
openaire   +7 more sources

Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of Borrelia burgdorferi Elp Proteins

Molecular Microbiology, EarlyView.
A novel approach using the Pseudomonas syringae ice nucleation protein (INP) system to present Borrelia burgdorferi lipoproteins on the surface of Escherichia coli reveals conservation of complement inhibitory functions among uncharacterized OspE/F‐like leader peptide (Elp) proteins.
Nathan Hill, Lara M. Matulina, Cameron MacIntyre, M. Amine Hassani, Sheila Thomas, Matteo Luban, Isabelle Ward, Amina Abdalla, John M. Leong, Brandon L. Garcia, Jacob E. Lemieux   +10 more
wiley   +1 more source

The Flagellin‐Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis

Molecular Microbiology, EarlyView.
FliS, a flagellin protein chaperon of the Lyme disease pathogen Borrelia burgdorferi, controls the cytoplasmic pool of flagellins (FlaB) at the level of translation initiation, secretion, and proteolysis. Deletion of fliS blocks FlaB secretion and translation initiation through a pattern‐switching mechanism of FliS‐FlaB‐FliW/CsrA. Therefore, the mutant
Ching Wooen Sze, Kai Zhang, Michael J. Lynch, Wangbiao Guo, Jun Liu, Brian R. Crane, Chunhao Li   +6 more
wiley   +1 more source

Spatial and temporal analyses of Dermacentor variabilis (Say) (Acari: Ixodidae) in central and eastern Canada

Medical and Veterinary Entomology, EarlyView.
One thousand one hundred ninety‐eight adult Dermacentor variabilis (Say), a species of veterinary and human medical importance, were collected from companion animals in central and eastern Canada. Peaks in adult D. variabilis submissions occurred in May and June across the provinces. Most submissions of adult D.
Grace K. Nichol, J. Scott Weese, Shaun J. Dergousoff, Amy L. Greer, Katie M. Clow   +4 more
wiley   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

Lyme disease: case report of persistent Lyme disease from Pulaski County, Virginia

International Medical Case Reports Journal, 2013
James R Palmieri,1 Scott King,1 Matthew Case,1 Arben Santo21Department of Microbiology, Infectious and Emerging Diseases, 2Department of Pathology, Edward Via College of Osteopathic Medicine, Blacksburg, VA, USAAbstract: A 50-year-old woman from Pulaski,
Palmieri JR, King S, Case M, Santo A
doaj  

Acute lyme infection presenting with amyopathic dermatomyositis and rapidly fatal interstitial pulmonary fibrosis: a case report

Journal of Medical Case Reports, 2010
Introduction Dermatomyositis has been described in the setting of lyme infection in only nine previous case reports. Although lyme disease is known to induce typical clinical findings that are observed in various collagen vascular diseases, to our ...
Nguyen Hanh, Le Connie, Nguyen Hien
doaj   +1 more source

Posting environmental risk: Communicating with numerical and nonnumerical messaging across information modalities

Risk Analysis, EarlyView.
Abstract Risk communicators frequently engage members of the public through social media; therefore, it is important to understand how to effectively communicate risks about environmental and health issues. This experiment with U.S. adults (N = 737) explored how message features in risk‐focused social media posts—namely, message modality (text‐only ...
Megan L. P. Norman, Jiaqi Agnes Bao, Triwik Kurniasari, Chris Skurka   +3 more
wiley   +1 more source

Navigating infection by pathogenic spirochetes: The host‐bacteria interface at the atomic level

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Pathogenic spirochetes bind and interact with various host structures and molecules throughout the course of infection. By utilizing their outer surface molecules, spirochetes can effectively modulate their dissemination, interact with immune system regulators, and select specific destination niches within the host.
Libor Hejduk, Norbert Müller, Adriana Rathner, Ján Štěrba, Shang‐Cheng Hung, Chia‐Lin Chyan, Ryan O. M. Rego, Martin Strnad   +7 more
wiley   +1 more source

Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH‐wildtype

Brain Pathology, Volume 35, Issue 4, July 2025.
The molecular profile of adult primary leptomeningeal gliomatosis closely aligned with that of adult‐type glioblastoma, IDH‐wildtype, CNS WHO grade 4. Abstract Adult primary leptomeningeal gliomatosis (PLG) is a rare, rapidly progressive and fatal disease characterized by prominent leptomeningeal infiltration by a glial tumor without an identifiable ...
Yi Zhu, Darin D. Carabenciov, Derek R. Johnson, Jorge A. Trejo‐Lopez, Aivi T. Nguyen, Aditya Raghunathan, Giuseppe Lanzino, Cristiane M. Ida, Cinthya J. Zepeda‐Mendoza, Surendra Dasari, Emilie Russler‐Germain, Sonika Dahiya, Martha Quezado, Kenneth Aldape, Caterina Giannini   +14 more
wiley   +1 more source