Results 111 to 120 of about 527,446 (319)

Spectral imaging as a potential tool for optical sentinel lymph node biopsies

We investigate the potential use of spectral imaging for performing an optical sentinel lymph node biopsy. Dummy images generated from previously published data are analysed using a spectral angle map and we conclude that there is scope for spectral ...
Rutt, Harvey, O'Sullivan, Jack, Hoy, Paul   +2 more
core  

Deep learning assisted non-invasive lymph node burden evaluation and CDK4/6i administration in luminal breast cancer

iScience
Summary: Precise lymph node evaluation is fundamental to optimize CDK4/6 inhibitor therapy in luminal breast cancer, particularly given contemporary trends toward axillary surgery de-escalation that may compromise traditional lymph node staging for ...
Yuhan Liu, Jinlin Ye, Zecheng He, Mingyue Wang, Changjun Wang, Jie Lang, Yidong Zhou, Wei Zhang   +7 more
doaj   +1 more source

The Argument and Consensus of Lymphadenectomy on Lung Cancer Surgery

Chinese Journal of Lung Cancer, 2018
Lymph node metastasis is an important route of metastasis of lung cancer. Lymphadenectomy has become the standard surgical procedure for lung cancer. The way of intraoperative lymph node assessment also affects the prognosis and treatment strategy of ...
Lanjun ZHANG
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Extended lymph node dissection for prostate cancer

, 2008
Lymph node status is an important determinant for the management of patients with newly diagnosed prostate cancer. Given the significant limitations of cross-sectional and functional preoperative imaging in the detection of small metastases, pelvic lymph
Jeschke, Stephan, Dhar, Nivedita, Thurairaja, Ramesh, Studer, Urs E, Burkhard, Fiona C   +4 more
core  

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform

Haematologica, 2018
Ingram Iaccarino, Lamis Afify, Sietse M. Aukema, Katharina Reddemann, Philipp Schütt, Martin Flür, Wolfram Klapper   +6 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

THE LYMPH NODE IN EXPERIMENTAL XANTHOMATOSIS*

, 2017
There is significant, progressive replacement of the lymplioid elements of the lymph node by foam cells in experimental xanthomatosis. These cells first form islands in the subcortical area. Subsequently they involve the medullary cords and finally, they
Mellins, HZ, Herman, PG, Yamamoto, I
core