Results 151 to 160 of about 527,446 (319)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Pelvic lymph node dissection in the context of radical cystectomy: a thorough insight into the connection between patient, surgeon, pathologist and treating institution

, 2013
Roland Seiler, George N Thalmann, Pascal ZehnderDepartment of Urology, University of Bern, Bern, SwitzerlandAbstract: Pelvic lymph node dissection (PLND) in patients with bladder cancer varies widely in extent, technique employed, and pathological workup
Seiler R, Zehnder P, Thalmann GN
core  

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Multifocality is associated with central neck lymph node metastases in papillary thyroid microcarcinoma

, 2018
Weihui Zheng,1 Kejing Wang,1 Junzhou Wu,2 Wendong Wang,1 Jinbiao Shang1 1Department of Head & Neck Surgery Zhejiang Cancer Hospital and Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, People’s ...
Wu J, Shang J, Wang W, Zheng W, Wang K
core  

Molecular profiling of primary renal marginal zone lymphoma reveals overlapping features with extranodal marginal zone lymphoma

Blood Advances
Axel Künstner, Vera von Kopylow, Philipp Lohneis, Matthias Kümmel, Hanno M. Witte, Veronica Bernard, Stephanie Stölting, Kathrin Kusch, Sivahari Gorantla, Manuela Krokowski, Nikolas von Bubnoff, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer   +14 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Molecular profiling of primary renal diffuse large B-cell lymphoma unravels a proclivity for immune-privileged tropism

Blood Advances
Axel Künstner, Vera von Kopylow, Philipp Lohneis, Matthias Kümmel, Hanno M. Witte, Lorenz Bastian, Veronica Bernard, Stephanie Stölting, Kathrin Kusch, Nikolas von Bubnoff, Konrad Steinestel, Annette Arndt, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer   +15 more
doaj   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

PREDICTIVE ROLE OF IMAGING IN SENTINEL LYMPH NODE DISSECTION FOR MELANOMA

, 2014
A retrospective study of 67 patients withmetastatic melanoma was performed toevaluate if imaging from lymphoscintigraphycould predict a higher miss rate if only themost radioactive node were removed.Following protocol for sentinel node biopsy,the surgeon
Avery, R, Ho, AM, Kuo, PH, Krupinski, EA, Warneke, J   +4 more
core  

Optimizing lymph node harvest in laparoscopic colorectal cancer: predictors and station-specific lymph node submission solutions. [PDF]

Ann Coloproctol
Gao C, Zhang S.
europepmc   +1 more source