Results 151 to 160 of about 783,580 (401)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients [PDF]

, 2013
Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being
ADHEMAR LONGATTO-FILHO, Akaishi, Al-Mulla, Al-Mulla, Baritaki, Baritaki, Bernier, Bonavida, BRUNO ZILBERSTEIN, CARLOS EDUARDO JACOB, Chatterjee, Chatterjee, Chen, CLÁUDIO BRESCIANI, Crew, Desai, Dicken, Fenoglio-Preiser, Fu, Fu, Gabbert, Granovsky, Greene, Hagan, Hori, Houben, IVAN CECCONELLO, Jazirehi, Jia, JOAQUIM GAMA-RODRIGUES, KLEBER SIMÕES, Klysik, Lauren, Lee, Li, Lorenz, Martinho, Martinho, Martinho, Milne, Ming, Minoo, Minoo, OLGA MARTINHO, Pinheiro, RUI MANUEL REIS, Schuierer, Schuierer, Seddiqi, Utsunomiya, Vauhkonen, VENÂNCIO ALVES, Wang, Washington, Yeung, Yeung, Yeung, Yonemura, Zaravinos, Zhang, Zlobec   +60 more
core   +1 more source

iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer [PDF]

, 2022
Sheetal Pathania, Mohd Imran Khan, Sabyasachi Bandyopadhyay, Suneet Shekhar Singh, Komal Rani, Tanvi Ramesh Parashar, Jnaneshwari Jayaram, Piyush Ranjan Mishra, Anurag Srivastava, Sandeep Mathur, Smriti Hari, Perumal Vanamail, Gururao Hariprasad   +12 more
openalex   +1 more source

Performance of CT in the Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis

American Journal of Neuroradiology, 2017
BACKGROUND AND PURPOSE: Ultrasound has become widely accepted as the first imaging technique used for the assessment of cervical lymph node metastasis in patients with papillary thyroid cancer. In this systematic review and meta-analysis, we evaluate the
C. Suh, J. Baek, Y. J. Choi, Jeong Hyun Lee   +3 more
semanticscholar   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression [PDF]

, 2012
Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma.
Cheng, Yun-Jie, Jing, Shao-Wu, Kuroda, Masahiro, Liu, Qing, Su, Jing-Wei, Sun, Guo-Gui, Wang, Ya-Di, Yang, Cong-Rong   +7 more
core   +1 more source

Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans [PDF]

, 2018
Ailin Qu, Yongmei Yang, Xin Zhang, Wenfei Wang, Yingjie Liu, Guixi Zheng, Lutao Du, Chuanxin Wang   +7 more
openalex   +1 more source

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

An ontology for carcinoma classification for clinical bioinformatics [PDF]

, 2005
There are a number of existing classifications and staging schemes for carcinomas, one of the most frequently used being the TNM classification.
Kumar, Anand, Marwede, Dirk, Novotny, Daniel, Smith, Barry, Yip, Yum Lina   +4 more
core  

Sentinel lymph node concept in gastric cancer with solitary lymph node metastasis

World Journal of Gastroenterology, 2004
To study the localization of the solitary metastases in relation to the primary gastric cancers and the feasibility of sentinel lymph node (SLN) concept in gastric cancer.Eighty-six patients with gastric cancer, who had only one lymph node involved, were regarded retrospectively as patients with a possible sentinel node metastasis, and the distribution
Li-Yang, Cheng, Shi-Zhen, Zhong, Zong-Hai, Huang   +2 more
openaire   +2 more sources