Results 141 to 150 of about 278,243 (313)

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Biomarkers of lymph node metastasis in colorectal cancer: update

Frontiers in Oncology
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths globally, trailing only behind lung cancer, and stands as the third most prevalent malignant tumor, following lung and breast cancers.
Xiao Zhu, Shui-quan Lin, Jun Xie, Li-hui Wang, Li-juan Zhang, Ling-ling Xu, Jian-guang Xu, Yang-bo Lv   +7 more
doaj   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Estudo da drenagem linfática do assoalho da boca e da borda da língua em suínos [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em Ciências MédicasIntrodução: Linfonodo sentinela é o primeiro linfonodo de uma cadeia linfonodal, que recebe a linfa de determinada ...
Foletto, Heldenrson
core  

Lymph Node Metastasis In Small Peripheral Adenocarcinoma Of The Lung

, 1998
Objective: Our aim in this study is to clarify the clinical and pathologic features of small peripheral adenocarcinoma of the lung with special emphasis on intraoperative identification of lymph node metastasis.
Yokoyama, Akira, Terashima, Masanori, Koike, Teruaki, Takizawa, Tsuneyo, Watanabe, Takehiro, Honma, Keiichi, Kurita, Yuzo   +6 more
core   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Lymph node metastasis of the rectal tumor.

, 2013
Lymph node metastasis of the rectal tumor.
Masashi Momiyama (483660), Hiroaki Kimura (53676), Robert M. Hoffman (302618), Ryoichi Aki (483661), Atsushi Suetsugu (437517), Toshiyoshi Fujiwara (157767), Hiroyuki Kishimoto (200624), Michael Bouvet (483662)   +7 more
core   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer

, 2012
Regional lymph node metastasis negatively affects prognosis in colon cancer patients. The molecular processes leading to regional lymph node metastasis are only partially understood and proteomic markers for metastasis are still scarce.
Höfler, Heinz, Axel Walch, Ueffing, Marius, Meding, S., Rosenberg, R., Sandra Rauser, Marius Ueffing, Höfler, H., Maak, Matthias, Hauck, Stefanie M, Walch, A.K., Rauser, Sandra, Stephan Meding, Langer, R., Stefanie M Hauck, Helmut Friess, Benjamin Balluff, Mareike Elsner, Cédrik Schöne, Schäfer, Alexander, Matthias Maak, Balluff, Benjamin, Langer, Rupert, Alexander Schäfer, Meding, Stephan, Rosenberg, Robert, Elsner, Mareike, Ulrich Nitsche, Schöne, C., Walch, Axel, Maak, M., Friess, H., Hauck, S.M., Nitsche, U., Ueffing, M., Heinz Höfler, Friess, Helmut, Rupert Langer, Balluff, B., Robert Rosenberg, Elsner, M., Rauser, S., Schöne, Cédrik, Schäfer, A., Nitsche, Ulrich   +44 more
core   +1 more source