Results 1 to 10 of about 369,774 (289)

Progression of Metastasis through Lymphatic System [PDF]

Cells, 2021
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits.
Timothy Padera, Hengbo Zhou, Pin-Ji Lei   +2 more
exaly   +4 more sources

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program

Cancer Communications, 2022
Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and ...
Wuguo Li, Ming Huang
exaly   +2 more sources

Tumor metastasis and the lymphatic vasculature

International Journal of Cancer, 2009
AbstractTumor‐associated lymphatic vessels act as a conduit by which disseminating tumor cells access regional lymph nodes and form metastases there. Lymph node metastasis is of major prognostic significance for many types of cancer, although lymph node metastases are themselves rarely life‐threatening.
Wilko Thiele, Jonathan Sleeman
exaly   +4 more sources

Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors [PDF]

Frontiers in Pharmacology
Metastasis is the leading cause of cancer-related death in cancer patients. Tumor cells primarily spread through the hematogenous and lymphatic system.
Ziyi Wang, Ziyi Wang, Ziyi Wang, Zehui Li, Xiangyu Sun, Wanfu Men, Yan Xu   +6 more
doaj   +2 more sources

Cancer-associated fibroblasts enhance colorectal cancer lymphatic metastasis via CLEC11A/LGR5-mediated WNT pathway activation [PDF]

The Journal of Clinical Investigation
Hypoxia in the tumor microenvironment promotes lymphatic metastasis, yet the role of cancer-associated fibroblasts (CAFs) in this process remains insufficiently elucidated in colorectal cancer (CRC).
Chuhan Zhang, Teng Pan, Yuyuan Zhang, Yushuai Wu, Anning Zuo, Shutong Liu, Yuhao Ba, Benyu Liu, Shuaixi Yang, Yukang Chen, Hui Xu, Peng Luo, Quan Cheng, Siyuan Weng, Long Liu, Xing Zhou, Jingyuan Ning, Xinwei Han, Jinhai Deng, Zaoqu Liu   +19 more
doaj   +2 more sources

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication [PDF]

Advanced Science
Lymphatic metastasis is a major cause of tumor treatment failure, with the immunosuppressive status of lymphatic macrophages significantly impairing antitumor immunity.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
doaj   +2 more sources

Long Non-Coding RNA MAPK8IP1P2 Inhibits Lymphatic Metastasis of Thyroid Cancer by Activating Hippo Signaling via Sponging miR-146b-3p

Frontiers in Oncology, 2021
The principal issue derived from thyroid cancer is its high propensity to metastasize to the lymph node. Aberrant exprssion of long non-coding RNAs have been extensively reported to be significantly correlated with lymphatic metastasis of thyroid cancer.
Xiaoli Liu, Qingfeng Fu, Xuehai Bian, Yantao Fu, Jingwei Xin, Nan Liang, Shijie Li, Yishen Zhao, Li Fang, Changlin Li, Jiao Zhang, Gianlorenzo Dionigi, Hui Sun   +12 more
doaj   +1 more source

Patterns of lymph node metastasis in level IIB and contralateral level VI for papillary thyroid carcinoma with pN1b and safety of low collar extended incision for neck dissection in level II

World Journal of Surgical Oncology, 2023
Objective To explore relevant clinical factors of level IIB and contralateral level VI lymph node metastasis and evaluate the safety of low-collar extended incision (LCEI) for lymph node dissection in level II for papillary thyroid carcinoma (PTC) with ...
Yudong Ning, Yuebai Liu, Dingfen Zeng, Yuqiu Zhou, Linjie Ma, Shuang Dong, Jianfeng Sheng, Gaosong Wu, Wen Tian, Yongcong Cai, Chao Li   +10 more
doaj   +1 more source

Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.

PLoS ONE, 2021
MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We
Zheying Zhang, Huijie Jia, Yuhang Wang, Baoshun Du, Jiateng Zhong   +4 more
doaj   +1 more source

Mechanisms of lymphatic metastasis [PDF]

Journal of Clinical Investigation, 2014
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor ...
Karaman Sinem, Detmar Michael
openaire   +2 more sources