Results 1 to 10 of about 95,502 (256)

Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling

Cancer Biology & Medicine, 2020
Objective: Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of cancer. However, few anti-lymphangiogenic drugs have been approved for clinical use to date. Therefore, new therapies to block lymphangiogenesis are
Tingting Qin, Zhujun Liu, Jing Wang, Junling Xia, Shaochuan Liu, Yanan Jia, Hailin Liu, Kai Li   +7 more
doaj   +1 more source

Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis

Neoplasia: An International Journal for Oncology Research, 2006
Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum ...
Robert B. Rebhun, Robert R. Langley, Kenji Yokoi, Dominic Fan, Jeffrey E. Gershenwald, Isaiah J. Fidler   +5 more
doaj   +1 more source

Surgical outcomes for cutaneous squamous cell carcinoma of the auricle

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2023
Background Cutaneous squamous cell carcinoma (CSCC) on the auricle is believed to carry a higher risk of metastatic spread. The rates of lymphatic metastasis reported in the literature have varied widely.
Constantin Manole, Liam J. Skinner, Martin J. Donnelly   +2 more
doaj   +1 more source

Mechanisms and Clinical Significance of Tumor Lymphatic Invasion

Cells, 2021
Tumor-associated lymphatic vessels play an important role in tumor progression, mediating lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating tumor immunity. An early, necessary step in the lymphatic metastasis cascade
Noriki Fujimoto, Lothar C. Dieterich
doaj   +1 more source

Risk factors for lymphatic and hematogenous metastasis after diagnosis of cutaneous Melanoma in Taiwan

Journal of the Formosan Medical Association, 2022
Background: Risk factors of lymphatic and hematogenous metastasis in cutaneous melanoma remained unclear in Asian population. This study aimed to identify clinical and histopathological factors to predict metastatic pathways in cutaneous melanoma in ...
Che-Chia Hsu, Tung-Lin Lee, Ming-Hsien Lin, Yi-Hua Liao, Jau-Yu Liau, Yi-Shuan Sheen   +5 more
doaj   +1 more source

Phenotypic alterations in the immune system and tolerance induction in tumor-draining lymph nodes [PDF]

Iranian Journal of Basic Medical Sciences
The cause of 90% of all cancer-related fatalities is metastasis. There are two main pathways for the spread of cancer cells: the blood and lymphatic systems. The underlying mechanism of lymphatic metastasis has been well established.
Zohreh Koohini, Mansoureh Karimi Kakh, Zeinab Rajabian, Zahra Koohini   +3 more
doaj   +1 more source

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +1 more source

Preoperative consolidation‐to‐tumor ratio is effective in the prediction of lymph node metastasis in patients with pulmonary ground‐glass component nodules

Thoracic Cancer, 2021
Background Preoperative positron emission tomography/computed tomography (PET/CT) is recommended as a guideline for staging of lung cancer. However, for patients with pulmonary ground‐glass opacity (GGO) nodules who are supposed to have a relatively low ...
Yi‐Chung Chen, Yi‐Han Lin, Hung‐Che Chien, Po‐Kuei Hsu, Jung‐Jyh Hung, Chien‐Sheng Huang, Chih‐Cheng Hsieh, Wen‐Hu Hsu, Han‐Shui Hsu   +8 more
doaj   +1 more source

Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma

World Journal of Surgical Oncology, 2017
Background Lymphatic metastasis contributes to the poor prognosis of laryngeal squamous cell carcinoma (LSCC). This study aimed to investigate the roles of two metastasis suppressor genes, KAI1 and nm23, in lymphangiogenesis and lymph metastasis of LSCC.
Zongzhu Zheng, Ruihua Tian, Ping Wang
doaj   +1 more source

Altered tumor microenvironment heterogeneity of penile cancer during progression from non‐lymphatic to lymphatic metastasis

Cancer Medicine
Background Lymphatic metastasis is the major challenge in the treatment of penile cancer. The prognosis of individuals with lymphatic metastasis is extremely poor.
Da‐Ming Xu, Xiao‐Yu Zhuang, Hua‐Li Ma, Zai‐Shang Li, Li‐Chao Wei, Jun‐Hang Luo, Hui Han   +6 more
doaj   +1 more source