Results 41 to 50 of about 400,896 (294)

Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling

Cancer Biology & Medicine, 2020
Objective: Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of cancer. However, few anti-lymphangiogenic drugs have been approved for clinical use to date. Therefore, new therapies to block lymphangiogenesis are
Tingting Qin, Zhujun Liu, Jing Wang, Junling Xia, Shaochuan Liu, Yanan Jia, Hailin Liu, Kai Li   +7 more
doaj   +1 more source

Phenotypic alterations in the immune system and tolerance induction in tumor-draining lymph nodes [PDF]

Iranian Journal of Basic Medical Sciences
The cause of 90% of all cancer-related fatalities is metastasis. There are two main pathways for the spread of cancer cells: the blood and lymphatic systems. The underlying mechanism of lymphatic metastasis has been well established.
Zohreh Koohini, Mansoureh Karimi Kakh, Zeinab Rajabian, Zahra Koohini   +3 more
doaj   +1 more source

Surgical outcomes for cutaneous squamous cell carcinoma of the auricle

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2023
Background Cutaneous squamous cell carcinoma (CSCC) on the auricle is believed to carry a higher risk of metastatic spread. The rates of lymphatic metastasis reported in the literature have varied widely.
Constantin Manole, Liam J. Skinner, Martin J. Donnelly   +2 more
doaj   +1 more source

Mechanisms and Clinical Significance of Tumor Lymphatic Invasion

Cells, 2021
Tumor-associated lymphatic vessels play an important role in tumor progression, mediating lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating tumor immunity. An early, necessary step in the lymphatic metastasis cascade
Noriki Fujimoto, Lothar C. Dieterich
doaj   +1 more source

Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis

Neoplasia: An International Journal for Oncology Research, 2006
Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum ...
Robert B. Rebhun, Robert R. Langley, Kenji Yokoi, Dominic Fan, Jeffrey E. Gershenwald, Isaiah J. Fidler   +5 more
doaj   +1 more source

Risk factors for lymphatic and hematogenous metastasis after diagnosis of cutaneous Melanoma in Taiwan

Journal of the Formosan Medical Association, 2022
Background: Risk factors of lymphatic and hematogenous metastasis in cutaneous melanoma remained unclear in Asian population. This study aimed to identify clinical and histopathological factors to predict metastatic pathways in cutaneous melanoma in ...
Che-Chia Hsu, Tung-Lin Lee, Ming-Hsien Lin, Yi-Hua Liao, Jau-Yu Liau, Yi-Shuan Sheen   +5 more
doaj   +1 more source

Lymphatic metastasis.

, 2018
Lymphatic metastasis.
Huifang Wu (2435029), Xiaohong Chen (220164), Hailin Wang (67695), Shouye Ma (5278499), Xiaoyan He (417003), Liang Yao (823113), Kehu Yang (192609)   +6 more
core   +1 more source

Biomechanical aspects of the normal and cancer-associated lymphatic system

, 2022
The presence of lymph node metastasis is a robust adverse prognostic marker in cancer patients. Solid cancers coopt the existing lymphatic system and induce lymphangiogenesis in the process of lymphatic metastatic spread.
Silvera Delgado, Carlos Alejandro, Salavati, Hooman, Silvera Delgado, Carlos Alejandro0001613948628020027288679738869890500000-0002-3882-7068A5E57C18-0A9C-11E7-BD1F-BED1AD28A064, Ceelen, WimeditorGE38UZGent0019852993038020006045670000-0001-7692-4419FE50E55E-F0ED-11E1-A9DE-61C894A0A6B4, Ceelen, Wim, Debbaut, CharlotteTW060020041569118020006022440000-0003-1962-238X0BE4CA0A-F0EE-11E1-A9DE-61C894A0A6B4, Adeli Koudehi, GhazalUGent0001412318958020025277939793799675930000-0002-3965-64245F7EB2EC-7040-11E4-A512-F7A7B5D1D7B1, Segers, PatrickTW068010008641650000-0003-3870-3409F4A2EB1A-F0ED-11E1-A9DE-61C894A0A6B4, Adeli Koudehi, Ghazal, Ceelen, WimGE38UZGent0019852993038020006045670000-0001-7692-4419FE50E55E-F0ED-11E1-A9DE-61C894A0A6B4, Debbaut, Charlotte, Salavati, HoomanGE380001913984778020033176380000-0001-5398-464634402fba-f9d7-11e9-9246-ced536015f62, Segers, Patrick   +12 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors

Frontiers in Pharmacology
Metastasis is the leading cause of cancer-related death in cancer patients. Tumor cells primarily spread through the hematogenous and lymphatic system.
Ziyi Wang, Ziyi Wang, Ziyi Wang, Zehui Li, Xiangyu Sun, Wanfu Men, Yan Xu   +6 more
doaj   +1 more source