Results 51 to 60 of about 95,502 (256)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic Metastasis via Epigenetic Regulation of FGF2‐Induced Lymphangiogenesis

Advanced Science
The lymph node is the most common site of distant metastasis of cervical squamous cell carcinoma (CSCC), which elicits dismal prognosis and limited efficiency for treatment. Elucidation of the mechanisms underlying CSCC lymphatic metastasis would provide
Chunyu Zhang, Li Yuan, Weijia Wen, Caixia Shao, Yuandong Liao, Yan Jia, Xueyuan Zhao, Yan Liao, Dingze Xu, Linna Chen, Guofen Yang, Hongye Jiang, Wei Wang, Shuzhong Yao   +13 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Clinical Significance of Lymphatic Infiltration Detected by Immunohistochemical Double Staining in Patients with Endometrial Cancer

Clinical Medicine Insights: Oncology, 2023
Background: The presence of lymph-vascular space invasion is a powerful predictor of lymph node metastasis. However, most studies do not distinguish lymph vessel invasion (LVI) and blood vessel invasion (BVI). The aim of this study was to distinguish the
Juan Xu, Xinmei Wang, Qiuyue Du, Pengpeng Qu, Caiyan Liu   +4 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids

Cell Death and Disease, 2023
Esophageal squamous cell carcinoma (ESCC) is one of the fatal malignancies worldwide. It has an increased propensity to metastasize via lymphogenous routes in an early stage.
Xiufeng Xie, Lusong Tian, Yan Zhao, Fang Liu, Shuyang Dai, Xinglu Gu, Yuxin Ye, Lanping Zhou, Xinmiao Liu, Yulin Sun, Xiaohang Zhao   +10 more
doaj   +1 more source

Analysis of lymph nodes metastasis in hypopharyngeal squamous cell carcinoma based on contrast‐enhanced computed tomography imaging

Precision Radiation Oncology, 2021
Objective To investigate the frequency, distribution, and potential factors of lymphatic metastasis at each nodal level, and stratify the risk of lymph node metastasis in hypopharyngeal squamous cell carcinoma based on computed tomography.
Dongqing Wang, Shuguang Zhang, Jin Xu, Limin Zhai, Baosheng Li   +4 more
doaj   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Integrin α6‐containing extracellular vesicles promote lymphatic remodelling for pre‐metastatic niche formation in lymph nodes via interplay with CD151

Journal of Extracellular Vesicles
Heterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation of pre‐metastatic “niches” in draining lymph nodes (LNs) to promote lymphatic metastasis.
Yan Lin, Hanhao Zheng, Linpei Jia, Yuming Luo, Dingwen Zhang, Mingjie An, Mingrui Pang, Xiayao Diao, Wenjie Li, Jiancheng Chen, Yuanlong Li, Daiyin Liu, Zhicong Liu, Jian Huang, Tianxin Lin, Changhao Chen   +15 more
doaj   +1 more source

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

Cell Reports, 2019
Summary: Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent signaling cascade that
Rachel Evans, Fabian Flores-Borja, Sina Nassiri, Elena Miranda, Katherine Lawler, Anita Grigoriadis, James Monypenny, Cheryl Gillet, Julie Owen, Peter Gordon, Victoria Male, Anthony Cheung, Farzana Noor, Paul Barber, Rebecca Marlow, Erika Francesch-Domenech, Gilbert Fruhwirth, Mario Squadrito, Borivoj Vojnovic, Andrew Tutt, Frederic Festy, Michele De Palma, Tony Ng   +22 more
doaj   +1 more source