Results 71 to 80 of about 369,774 (289)

Clinical Significance of Lymphatic Infiltration Detected by Immunohistochemical Double Staining in Patients with Endometrial Cancer

Clinical Medicine Insights: Oncology, 2023
Background: The presence of lymph-vascular space invasion is a powerful predictor of lymph node metastasis. However, most studies do not distinguish lymph vessel invasion (LVI) and blood vessel invasion (BVI). The aim of this study was to distinguish the
Juan Xu, Xinmei Wang, Qiuyue Du, Pengpeng Qu, Caiyan Liu   +4 more
doaj   +1 more source

Sentinel Node and Mechanism of Lymphatic Metastasis

Annals of Vascular Diseases, 2012
The validity and clinical usefulness of the sentinel node (SN) concept for breast cancer has been confirmed, and individualized limited surgery based on diagnosis of SN metastasis is presently performed. In the future, SN navigation surgery (SNNS) will be actively applied to the treatment of early gastric cancer, and an intraoperative real-time reverse
Takeuchi, Hiroya, Kitagawa, Yuko
openaire   +3 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Modelling the fluid drainage through primary lymphatic valves

, 2013
This study investigates the fluid flow through tissues where lymphatic drainage occurs. Lymphatic drainage relies on two unidirectional valve systems, primary and secondary.
Heppell, Charles
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer

Nature Communications, 2021
The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3
Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song   +14 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids

Cell Death and Disease, 2023
Esophageal squamous cell carcinoma (ESCC) is one of the fatal malignancies worldwide. It has an increased propensity to metastasize via lymphogenous routes in an early stage.
Xiufeng Xie, Lusong Tian, Yan Zhao, Fang Liu, Shuyang Dai, Xinglu Gu, Yuxin Ye, Lanping Zhou, Xinmiao Liu, Yulin Sun, Xiaohang Zhao   +10 more
doaj   +1 more source

An experimental model for lymphatic metastasis in rats.

Gan, 1976
An experimental model was described for inducing spontaneous lymph node metastasis, in which tumor cells of the rat ascites hepatoma AH-109A were transplanted into the subcutaneous tissue of the penis, which is rich of lymph plexus. Growth of tumor at the site of transplantation was measured serially and metastasis was recognized by palpation in the ...
TAKAZAWA, Hiroshi, SHIMIZU, Shizuko
openaire   +2 more sources

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. [PDF]

, 2004
Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors.
Jackson, D.G., Clasper, Steve, Dagmar Galter, Ohhashi, T, Dissing, S., Steen Dissing, Meit A. Björndahl, Garvin, S., Cao, Yihai, Steve Clasper, Katerina Tritsaris, Meister, B., Religa, P., Religa, Piotr, Garvin, Stina, Clasper, S., Ohhashi, Toshio, Fumitaka Ikomi, Ikomi, Fumitaka, Ikomi, F., Garvin, S, Cao, R., Tritsaris, K., Cao, Y, Bjorndahl, M.A., Björndahl, Meit A., Toshio Ohhashi, Cao, R, Dissing, S, Jackson, DG, Ohhashi, T., Religa, P, Dissing, Steen, Björn Meister, Cao, Renhai, Galter, D., Galter, D, Tritsaris, Katerina, Cao, Y., Ikomi, F, Clasper, S, Jackson, David G., Stina Garvin, Meister, Björn, Renhai Cao, Galter, Dagmar, Björndahl, MA, David G. Jackson, Yihai Cao, Meister, B, Tritsaris, K, Piotr Religa   +51 more
core   +1 more source