Results 81 to 90 of about 369,774 (289)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Integrin α6‐containing extracellular vesicles promote lymphatic remodelling for pre‐metastatic niche formation in lymph nodes via interplay with CD151

Journal of Extracellular Vesicles
Heterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation of pre‐metastatic “niches” in draining lymph nodes (LNs) to promote lymphatic metastasis.
Yan Lin, Hanhao Zheng, Linpei Jia, Yuming Luo, Dingwen Zhang, Mingjie An, Mingrui Pang, Xiayao Diao, Wenjie Li, Jiancheng Chen, Yuanlong Li, Daiyin Liu, Zhicong Liu, Jian Huang, Tianxin Lin, Changhao Chen   +15 more
doaj   +1 more source

Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?

Oncogenesis, 2021
Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Sini Karinen, Krista Juurikka, Roosa Hujanen, Wafa Wahbi, Elin Hadler-Olsen, Gunbjørg Svineng, Kari K. Eklund, Tuula Salo, Pirjo Åström, Abdelhakim Salem   +9 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

Cell Reports, 2019
Summary: Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent signaling cascade that
Rachel Evans, Fabian Flores-Borja, Sina Nassiri, Elena Miranda, Katherine Lawler, Anita Grigoriadis, James Monypenny, Cheryl Gillet, Julie Owen, Peter Gordon, Victoria Male, Anthony Cheung, Farzana Noor, Paul Barber, Rebecca Marlow, Erika Francesch-Domenech, Gilbert Fruhwirth, Mario Squadrito, Borivoj Vojnovic, Andrew Tutt, Frederic Festy, Michele De Palma, Tony Ng   +22 more
doaj   +1 more source

Analysis of lymph nodes metastasis in hypopharyngeal squamous cell carcinoma based on contrast‐enhanced computed tomography imaging

Precision Radiation Oncology, 2021
Objective To investigate the frequency, distribution, and potential factors of lymphatic metastasis at each nodal level, and stratify the risk of lymph node metastasis in hypopharyngeal squamous cell carcinoma based on computed tomography.
Dongqing Wang, Shuguang Zhang, Jin Xu, Limin Zhai, Baosheng Li   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Comparative Proteomics Analysis of Lymphatic Metastasis-associated Proteins of Highly and Low Lymphatic Metastatic Potentiality in Mouse Hepatocarcinoma Cell Lines Using Reductive Dimethylation-coupled HPLC-Chip ESI-QTOF

, 2011
Comparative Proteomics Analysis of Lymphatic Metastasis-associated Proteins of Highly and Low Lymphatic Metastatic Potentiality in Mouse Hepatocarcinoma Cell Lines Using Reductive Dimethylation-coupled HPLC-Chip ESI ...
陶定银, 袁辉明, 张玉奎, 周愿, 张丽华   +4 more
core   +1 more source