Results 101 to 110 of about 369,774 (289)

Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer

, 2011
Lymphatic metastasis constitutes a critical route of disease dissemination, which limits the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC).
Hilfenhaus, G., Hauff, P., Hilfenhaus, Georg, Frauke Alves, Schulz, P., Boehmig, M., Arne Scholz, Thierauch, K.H., Kehrberger, Jenny, Rieke, Svenja, Hauff, Peter, Michael Böhmig, Alves, F., Fischer, Christian, Detjen, Katharina M., Schulz, Petra, Boehmig, Michael, Peter Hauff, Inga Koch, von Marschall, Z., Katharina M. Detjen, Thierauch, Karl Heinz, Alves, Frauke, Rieke, S., Petra Schulz, Kehrberger, J., Svenja Rieke, Christian Fischer, Koch, I., Scholz, A., Jenny Kehrberger, Wiedenmann, B., von Marschall, Zofia, Georg Hilfenhaus, Zofia Marschall, Fischer, C., Karl Heinz Thierauch, Wiedenmann, Bertram, Bertram Wiedenmann, Koch, Inga, Scholz, Arne, Detjen, K.M.   +41 more
core   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Controlled Trans-lymphatic Delivery of Chemotherapy for the Treatment of Lymphatic Metastasis in Lung Cancer [PDF]

, 2008
Lymph node metastasis is a critical prognostic factor for lung cancer. Effective therapy to control lymphatic metastasis may improve survival. The work described in this thesis focuses on the development of a microparticulate lymphatic targeting system,
Liu, Jiang
core   +2 more sources

Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis

Scientific Reports, 2018
Lymphatic metastasis is known to contribute to worse prognosis of biliary tract cancer (BTC). Recently, sphingosine-1-phosphate (S1P), a bioactive lipid mediator generated by sphingosine kinase 1 (SPHK1), has been shown to play an important role in ...
Yuki Hirose, Masayuki Nagahashi, Eriko Katsuta, Kizuki Yuza, Kohei Miura, Jun Sakata, Takashi Kobayashi, Hiroshi Ichikawa, Yoshifumi Shimada, Hitoshi Kameyama, Kerry-Ann McDonald, Kazuaki Takabe, Toshifumi Wakai   +12 more
doaj   +1 more source

The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma

Journal of Experimental & Clinical Cancer Research, 2009
Background To investigate the role of vascular endothelial growth factors (VEGF)-C/D and their receptor Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma.
Zhang Renhua, Zhang Shiqian, Yu Hao, Zhang Linlin   +3 more
doaj   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Insights into the biology of lymphatic metastasis

, 2006
Recent data suggest that the generation of new lymphatic vessels (i.e. lymphangiogenesis) may be a rate-limiting step in the dissemination of tumor cells to regional lymph nodes. However, efforts to study the cellular and molecular interactions that take
Rebhun, Robert B
core   +1 more source

LYMPHATIC METASTASIS IN CANCER OF THE RECTUM

The Japanese Journal of Gastroenterological Surgery, 1979
最近3年間の拡大郭清を伴う直腸癌治癒切除例76例について郭清リンパ節を詳細に検索し, リンパ節転移を検討した.上方転移は39例, 51%にみられた.側方転移は15例, 20%にみられたが, 転移リンパ節数は1～4個, 平均1.6個と少なく, 15例中14例は1ヵ所だけに転移を生じていた.側方転移部位は内腸骨リンパ筋が6例と最も多く, 中直腸根リンパ節・4例, 閉鎖リンパ節・3例で次に多い.とくに中直腸根リンパ節は術中に腫張のみられたもののうち75%の頻度で転移がみられた.
Yoshihiro OMY, Shigeo OKI, Tadao KANAI, Yoshio MATSUDA, Hideo EGUCHI, Takehiko INUO, Shuji TSUTIYA   +6 more
openaire   +2 more sources

The contribution of bone marrow-derived cells to angiogenesis and lymphangiogenesis in murine models of carcinogenesis [PDF]

, 2009
Cancer is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via ...
Zumsteg, Adrian
core   +1 more source