Results 161 to 170 of about 783,580 (401)

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

Noninvasive Imaging of CD206-Positive M2 Macrophages as an Early Biomarker for Post-Chemotherapy Tumor Relapse and Lymph Node Metastasis

Theranostics, 2017
Tumor relapse after initial regression post-chemotherapy is a major challenge in cancer treatment, as it usually leads to local-regional recurrence or inoperable distant metastasis.
Chenran Zhang, Xinhe Yu, Liquan Gao, Yang Zhao, Jianhao Lai, D. Lu, Rui Bao, Bing Jia, Lijun Zhong, Fan Wang, Zhaofei Liu   +10 more
semanticscholar   +1 more source

[Hidradenocarcinoma of the Scrotum with Lymph Node Metastasis].

Acta medica portuguesa, 2018
Hidradenocarcinoma is a rare neoplasm of the eccrine cells of the sweat glands, usually asymptomatic with slow growing and higher incidence between 50 and 80 years, occurring in both sexes and preferentially located in the palmar, plantar, frontal, axillary and nuchal regions.
Maria Inês Simões, Isabel Marcão, Mário Toscano, Luís Borges   +3 more
openaire   +2 more sources

Patterns of lymph node metastasis of parotid cancer

Nippon Jibiinkoka Gakkai Kaiho, 2016
To define the incidence and pattern of spread of lymph node metastasis from parotid cancers and to clarify the risk factors and appropriate extent of neck dissection (ND) for individual patient with parotid cancer.A total of 72 patients with parotid gland cancer treated by surgery between 1994 and 2013 were analyzed retrospectively by reference to ...
Hitomi, Shinomiya, Naoki, Otsuki, Daisuke, Yamashita, Ken-Ichi, Nibu   +3 more
openaire   +3 more sources

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Model based on preoperative clinical characteristics to predict lymph node metastasis in patients with gastric cancer [PDF]

, 2022
Baicheng Ding, Pan-Quan Luo, Jiahui Yong
openalex   +1 more source

Two cases with mediastinal lymph node metastasis and hilar lymph node metastasis of unknown origin.

The Journal of the Japanese Association for Chest Surgery, 1997
原発不明癌のうちリンパ節転移で発見されるものは頸部, 鎖骨上リンパ節転移が多いが, 縦隔, 肺門リンパ節転移で発見されることは稀である。今回原発不明縦隔, 肺門リンパ節転移の2例を経験した.症例1は65歳男性で脾臓腫瘍摘出後, 右肺門部異常陰影で発見され, 症例2は74歳女性で, 検診の胸部X線写真で縦隔異常陰影として発見された.症例1は原発性肺癌の診断で右中下葉切除, R2a郭清を施行し, 症例2は縦隔腫瘍として手術したため腫瘍摘出術のみ施行した.術後病理学的には, それぞれ腺癌, 扁平上皮癌のリンパ節転移であった.術後原発巣検索のため全身の精査を行ったが, 未だ原発巣の発見には至っていない.今後も肺を中心に胸郭外臓器癌からの転移も考慮に入れ検索してゆく必要がある.
Tohru Sato, Yoshiki Naruke
openaire   +2 more sources

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy

Advanced Science, EarlyView.
The fused EV platform AS16‐EL@MPLA/p‐FX reprograms tumor cells into cytokine‐producing factories that continuously secrete XCL1 and FLT3L to recruit and differentiate cDC1s, while embedded MPLA activates them through TLR4 signaling and AS16 prevents their exhaustion, thereby enhancing antitumor immunity and establishing durable immune memory against ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
wiley   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source