ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita +4 more
wiley +1 more source
miR-1287-5p as a Biomarker for Predicting Lymph Node Metastasis in Gastric Cancer Patients. [PDF]
Zhang J, Zhang M, Zhao W, Wu H, Wang R.
europepmc +1 more source
Posthumously Diagnosed Myhre Syndrome Presenting With Pleural Remodeling and Endometrial Cancer
ABSTRACT Myhre syndrome (OMIM 139210) is a genetic condition defined by neurodevelopmental disability, characteristic facial features, and multisystem proliferative fibrosis. While various types of lung disease have been reported, pleural remodeling leading to restrictive lung disease has not yet been described.
Jeanette Saffir +6 more
wiley +1 more source
Machine learning to develop and validate a model for predicting the risk of lymph node metastasis in colorectal cancer patients. [PDF]
Xia C +8 more
europepmc +1 more source
Establishment and characterization of mouse lymph node fibrosis models
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu +8 more
wiley +1 more source
Integration of Preoperative Neutrophil-to-Lymphocyte Ratio into Machine Learning Models for Predicting Lymph Node Metastasis in CRC. [PDF]
Zhang Y +7 more
europepmc +1 more source
ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim +10 more
wiley +2 more sources
Association between ultrasound radiomics features and central lymph node metastasis in patients with papillary thyroid carcinoma. [PDF]
Zhang Z, Wang Z, Li W, Yin Z.
europepmc +1 more source
The prognostic significance of sentinel lymph node biopsy in malignant melanoma [PDF]
Liszkay Gabriella
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