Results 241 to 250 of about 2,036,397 (332)

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

open access: yesAdvanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan   +11 more
wiley   +1 more source

Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes. [PDF]

open access: yesBrain
Al-Diwani A   +11 more
europepmc   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

open access: yesAdvanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu   +12 more
wiley   +1 more source

Staging Aortopulmonary Lymph Nodes With Robotic-Assisted Bronchoscopy: A Case Report and Literature Review. [PDF]

open access: yesRespirol Case Rep
Vaca-Cartagena BF   +10 more
europepmc   +1 more source

Material design for lymph node drug delivery

open access: yesNature Reviews Materials, 2019
A. Schudel, David M. Francis, S. Thomas
semanticscholar   +1 more source

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

open access: yesAdvanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen   +9 more
wiley   +1 more source

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