Results 51 to 60 of about 498,192 (310)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]

open access: yes, 2010
Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
core   +1 more source

CT differentiation of enlarged mediastinal lymph node due to anthracosis from metastatic lymphadenopathy: a comparative study proven by endobronchial US-guided transbronchial needle aspiration

open access: yesDiagnostic and Interventional Radiology, 2015
PURPOSEAnthracosis often results in mediastinal nodal enlargement. The aim of this comparative study was to evaluate if it is possible to differentiate endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) proven anthracotic lymph ...
Johannes Kirchner   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

The further assessment of a handheld Raman spectroscopy probe for the intraoperative diagnosis of axillary lymph nodes in breast cancer [PDF]

open access: yes, 2012
Axillary sentinel lymph node biopsy plays an important role in breast cancer management in determining further surgical and medical treatment options.
Tydeman, C.
core  

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice [PDF]

open access: yes, 2007
Two-photon imaging has revealed an elegant choreography of motility and cellular interactions within the lymph node under basal conditions and at the initiation of an immune response (1). Here, we present methods for adoptive transfer of labeled T cells,
Melanie P Matheu   +5 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

MORPHOMETRIC OBSERVATIONS ON LYMPH NODES IN GOAT FOETUSES [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2011
Prenatal studies on the biometry of the developing lymph nodes in goat were conducted in 41 foetuses. There was a progressive increase in the size of the lymph nodes, viz. mean length, width, thickness and weight of lymph nodes as the age advanced.
A. Asha   +3 more
doaj  

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