Results 121 to 130 of about 13,250 (289)

Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells [PDF]

, 2014
Lymphangioleiomyomatosis (LAM) is a female-predominant interstitial lung disease that can lead to respiratory failure. LAM cells typically have inactivating TSC2 mutations, leading to mTORC1 activation.
Blenis, J, Gerbaudo, V H, Gu, X, Henske, E P, Li, C, Morrison, T, Park, M-A, Pereira, A M, Sun, Y, Wang, S, Yu, J J, Zhang, E   +11 more
core   +1 more source

Extrapulmonary manifestation of lymphangioleiomyomatosis.

Journal of the Belgian Society of Radiology, 2015
A 31-year-old female patient presented at the department of hematology with painful nodal swellings in the neck region for 2 months. Four weeks before presentation, she had an airway infection during which the nodes were swollen. Since 10 days she suffered from dyspnea, a dry cough and a burning ache in the chest.
R. Gosselin, S. F. Van Meerbeeck, N. Favoreel   +2 more
openaire   +6 more sources

Lymphangioleiomyomatosis: a clinical review

Breathe, 2020
Lymphangioleiomyomatosis (LAM) is a diffuse cystic lung disease. There are two main types of LAM: sporadic, and LAM associated with the tuberous sclerosis complex (TSC), which is caused by mutations in the TSC1 and TSC2 genes.
A. O'Mahony, E. Lynn, D. Murphy, A. Fabre, C. McCarthy   +4 more
semanticscholar   +1 more source

Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy

Epilepsia, Volume 66, Issue 4, Page 1288-1303, April 2025.
Abstract Objective Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most important causes of morbidity in adult people with TSC (pwTSC).
Renaud Balthazard, Rose‐Marie Drouin‐Engler, Samuel Bertrand, Faycal Zine‐Eddine, Jimmy Li, Olivier Tastet, Audrey Daigneault, Victoria H. Mamane, Gloria Gabrielle Ortega‐Delgado, Alina Maria Sreng Flores, Daniel E. Kaufmann, Philippe Major, Andrew A. House, Laurent Létourneau‐Guillon, Nathalie Arbour, Mark R. Keezer, Catherine Larochelle   +16 more
wiley   +1 more source

Low-dose sirolimus in retroperitoneal lymphangioleiomyomas

Lung India, 2019
Lymphangioleiomyomatosis (LAM) is a rare disease associated with cystic lung destruction and abdominal tumors, including lymphangioleiomyomas, which frequently occur in the retroperitoneal region.
Kamonpun Ussavarungsi, Archana T Laroia, Charles D Burger   +2 more
doaj   +1 more source

Improvement of lung preservation - From experiment to clinical practice [PDF]

, 2002
Background. Reperfusion injury represents a severe early complication following lung transplantation. Among the pathogenetic factors, the high potassium content of Euro-Collins(R) solution is discussed.
Bittmann, I., Fürst, H., Hatz, Rudolf A., Kellner, B., Müller, Ch., Reichart, B., Schelling, G., Schildberg, Friedrich Wilhelm   +7 more
core   +1 more source

Solitary subependymal giant cell astrocytoma lacking TSC1/2 mutations and TTF‐1 expression: A potential diagnostic pitfall

Neuropathology, Volume 45, Issue 2, Page 167-173, April 2025.
Subependymal giant cell astrocytoma (SEGA) is a rare, low‐grade glioma typically associated with tuberous sclerosis (TS) and mutations in the TSC1 or TSC2 genes. It is characterized by an intraventricular location, an expansive growth pattern, and the expression of glial and neural markers.
Davide Mulone, Andrea Mafficini, Evelina Miele, Francesco Sala, Valeria Barresi   +4 more
wiley   +1 more source

Incidental Primary Angiomyolipoma of Ovary: A Rare Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 3, March 2025.
ABSTRACT Primary angiomyolipomas of the ovary which are not associated with genetical systemic diseases, particularly tuberous sclerosis, are extremely rare and are more likely to pose diagnostic challenges. This tumor, particularly of epithelioid variant, is more likely to be malignant and can carry a high possibility of metastasizing.
James J. Yahaya, Emmanuel D. Morgan, Veronica Nyakato, Emmanuel Othieno   +3 more
wiley   +1 more source

The efficacy and safety of pharmacological treatments for lymphangioleiomyomatosis

Respiratory Research, 2020
Background Lymphangioleiomyomatosis (LAM) is a rare, low-grade multisystem neoplastic disease . Most LAM patients are at a high risk of losing lung function at an accelerated rate and developing progressive dyspnea.
Qi Wang, M. Luo, B. Xiang, Siyuan Chen, Yi Ji   +4 more
semanticscholar   +1 more source

Ultrasensitive 129Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing

Advanced Science, Volume 12, Issue 8, February 24, 2025.
Ultrasensitive 129Xe magnetic resonance imaging (MRI) is a novel clinically approved technology that overcomes the sensitivity limitations of traditional 1H MRI by introducing hyperpolarized 129Xe as the signal source. This review summarizes recent advancements in 129Xe MRI, covering its principles, methodologies, applications ranging from clinical ...
Yuqi Yang, Sen Yue, Luyang Shen, Huiling Dong, Haidong Li, Xiuchao Zhao, Qianni Guo, Xin Zhou   +7 more
wiley   +1 more source