Retroperitoneal Lympathic Malformations as First Presentation of Lymphangioleiomyomatosis
Journal of the Belgian Society of Radiology, 2021 Teaching Point: This case highlights the extrapulmonary lymphatic abnormalities that may be associated with pulmonary lymphangioleiomyomatosis.
Christine Lenfant, Cristina Anca Dragean
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Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammation
, 2023 BACKGROUND Lymphedema is a global health problem with no effective drug treatment. Enhanced T cell immunity and abnormal lymphatic endothelial cell (LEC) signaling are promising therapeutic targets for this condition.
Dongeon Kim +17 more
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RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
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Prevalence and Cause of Early Fontan Complications: Does the Lymphatic Circulation Play a Role?
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Recent studies suggest that lymphatic congestion plays a role in development of late Fontan complications, such as protein‐losing enteropathy.
Reena M. Ghosh +11 more
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Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis [PDF]
, 2019 Mucosal surfaces play a central role in the pathogenesis of rheumatoid arthritis (RA). Several risk factors, such as cigarette smoking, environmental pollution, and periodontitis interact with the host at the mucosal level, triggering immune system ...
Conti, Fabrizio +5 more
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Molecular Mechanisms Controlling Lymphatic Endothelial Junction Integrity
Frontiers in Cell and Developmental Biology, 2021 The lymphatic system is essential for lipid absorption/transport from the digestive system, maintenance of tissue fluid and protein homeostasis, and immune surveillance.
Pieter R. Norden, Tsutomu Kume
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]
, 2020 Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J +3 more
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Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation
Frontiers in Physiology, 2022 The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive ...
Naoto Ujiie, Tsutomu Kume
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Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]
, 2010 Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Becker, Bernhard F. +8 more
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Utilizing lymphatic cell markers to visualize human lymphatic abnormalities [PDF]
Journal of Biophotonics, 2017 In vivo visualization of the human lymphatic system is limited by the mode of delivery of tracing agents, depth of field and size of the area examined, and specificity of the cell markers used to distinguish lymphatic endothelium from the blood vessels and the surrounding tissues.
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