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Gastrointestinal lymphatics in health and disease [PDF]

Pathophysiology, 2009
Lymphatics perform essential transport and immune regulatory functions to maintain homeostasis in the gastrointestinal (GI) system. Although blood and lymphatic vessels function as parallel and integrated systems, our understanding of lymphatic structure, regulation and functioning lags far behind that of the blood vascular system. This chapter reviews
J. Steven Alexander, Vijay C. Ganta, Paul Jordan, Marlys H. Witte   +3 more
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Immunopathogenesis of lymphatic filarial disease [PDF]

Seminars in Immunopathology, 2012
Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ~40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, tropical pulmonary eosinophilia, lymphedema, and (in its most severe form)
Subash Babu, Thomas B. Nutman
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The lymphatics in kidney health and disease [PDF]

Nature Reviews Nephrology, 2021
The mammalian vascular system consists of two networks: the blood vascular system and the lymphatic vascular system. Throughout the body, the lymphatic system contributes to homeostatic mechanisms by draining extravasated interstitial fluid and facilitating the trafficking and activation of immune cells. In the kidney, lymphatic vessels exist mainly in
Michael D. Donnan, Yael Kenig-Kozlovsky, Susan E. Quaggin   +2 more
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Lymphatic Connexins and Pannexins in Health and Disease [PDF]

International Journal of Molecular Sciences, 2021
This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic ...
Avigail Ehrlich, Filippo Molica, Aurélie Hautefort, Brenda R. Kwak   +3 more
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Lymphatic Function in Autoimmune Diseases [PDF]

Frontiers in Immunology, 2019
Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the
Noa Schwartz, Noa Schwartz, Madhavi Latha S. Chalasani, Thomas M. Li, Zhonghui Feng, William D. Shipman, William D. Shipman, Theresa T. Lu, Theresa T. Lu, Theresa T. Lu, Theresa T. Lu   +10 more
doaj   +3 more sources

Hypertension: a lymphatic disease? [PDF]

Clin Sci (Lond)
Hypertension affects nearly one in two American adults and is a major risk factor for cardiovascular events and organ damage. Many treatments exist to lower blood pressure in hypertensive patients; however, their degree of effectiveness varies.
Konatham S, Goodlett BL, Smith HL, Mitchell BM.   +3 more
europepmc   +2 more sources

Congenital Vascular and Lymphatic Diseases. [PDF]

Circ Res
Over the past several centuries, the integration of contemporary medical techniques and innovative technologies, like genetic sequencing, have played a pivotal role in enhancing our comprehension of congenital vascular and lymphatic disorders. Nonetheless, the uncommon and complex characteristics of these disorders, especially considering their ...
Jung R, Trivedi CM.
europepmc   +3 more sources

Lymphatic-immune interactions in the musculoskeletal system [PDF]

Frontiers in Immunology
Traditionally, the role of lymphatic vessels has been understood as primarily involving fluid transport and immune surveillance. In addition to these roles, recent studies have revealed a paracrine function of lymphatics through the dissemination of ...
Hanyu Liu, Lu Liu, Yuheng Zhang, Qi Tian, Zhangfan Ding, Zhangfan Ding, Junyu Chen, Junyu Chen, Anjali P. Kusumbe, Anjali P. Kusumbe   +9 more
doaj   +2 more sources

Targeting lymphatics in inflammatory bowel disease

Oncotarget, 2015
The inflammatory bowel diseases (IBDs), consisting of ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation of the gastrointestinal tract in genetically susceptible individuals exposed to environmental risk factors.
Silvia D’Alessio, Carlotta Tacconi, Silvio Danese   +2 more
openalex   +4 more sources

Advances in the Understanding of ocular and nasal lymphatics [PDF]

BMC Immunology
Recent research advancements have enhanced our understanding of the lymphatic system in the eye and nasal region and its involvement in health and disease. The eye is an anatomical extension of the central nervous system and was previously believed to be
Min Yan, Lu Cheng, Zheng Zheng, Yuanxi Lin, Doudou Qin, Hui Chen   +5 more
doaj   +2 more sources