Results 291 to 300 of about 9,431,933 (366)

Tumor‐Tissue Boundaries as Instructive Interfaces in Breast Cancer Cell Invasion

Advanced Science, EarlyView.
Tumor‐tissue boundaries reprogram metastatic breast cancer cells, enhancing invasiveness through an instructive, not permissive, mechanism. Using a 3D collagen I‐based tumor‐tissue interface model, single‐cell analysis, and simulations, this study shows that all cells can transmigrate without selective filtering, highlighting a targetable process in ...
Cornelia Clemens, Thomas Zerjatke, Andrine Frank, Hannah Trampert, Nataliia Kotsiuba, Ingmar Glauche, Tilo Pompe   +6 more
wiley   +1 more source

Cerebrospinal fluid flow modulates brain health. [PDF]

J Clin Invest
Hablitz LM, Nedergaard M.
europepmc   +1 more source

Advanced Image‐Guidance and Surgical‐Navigation Techniques for Real‐Time Visualized Surgery

Advanced Science, EarlyView.
This review comprehensively summarizes advances in surgical navigation, covering both established and emerging intraoperative imaging technologies. It highlights mechanisms, advantages, limitations, and clinical applications, while emphasizing interdisciplinary collaboration.
Xiaoxiao Fan, Xiaolong Liu, Qiming Xia, Guoqiao Chen, Jiaxi Cheng, Zhaoqi Shi, Yifeng Fang, Parikshit Asutosh Khadaroo, Jun Qian, Hui Lin   +9 more
wiley   +1 more source

Zoonotic brugian filariasis past and present trends in malaysia: A systematic review and proportionate meta-analysis. [PDF]

Sci Rep
Hafizu MS, Junaid OQ, Sagara R, Ravi R, Yik FM, Vythilingam I, Ling LY.   +6 more
europepmc   +1 more source

Lung lymphatic endothelial cells undergo inflammatory and prothrombotic changes in a model of chronic obstructive pulmonary disease [PDF]

Anjali Trivedi, Tyler M. Lu, Barbara D. Summers, Kihwan Kim, Alexander J. Rhee, Sean Houghton, Derek E. Byers, Raphaël Lis, Hasina Outtz Reed   +8 more
openalex   +1 more source

Intravenous iRGD‐Guided, RBC‐Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD‐1 Blockade

Advanced Science, EarlyView.
This study presents an engineered probiotic platform, iRGD‐mRBC@FOLactis, combining red blood cell membrane cloaking and tumor‐penetrating peptide iRGD for enhanced PD‐1 blockade. The platform improves tumor targeting, immune cell activation and therapeutic efficacy in lung cancer, demonstrating significant promise in overcoming PD‐1/PD‐L1 therapy ...
Chen Chen, Junmeng Zhu, Xiao Liu, Jie Shao, Aoxing Chen, Yi Mei, Xinyin Zhang, Qinyi Chen, Lin Li, Baorui Liu   +9 more
wiley   +1 more source

Lymphangiomatosis with pulmonary, mediastinal, and spinal involvement in a pediatric patient: a case report. [PDF]

BMC Pediatr
Sun Y, Zhou J, Hu X, Li M, Tan L.
europepmc   +1 more source

BACE2‐Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia

Advanced Science, EarlyView.
Vascular endothelial growth factor (VEGF)‐C secreted by Pi16+ fibro‐progenitors lays the foundation of lymphatic network in mouse arteriovenous fistulas (AVFs), whereas the elevated phosphate (Pi) in 5/6‐nephrectomy (Nx) mouse activates p‐ERK/p‐SP1/BACE2 pathway to generate additional soluble VEGFR‐3, which causes VEGF‐C unresponsiveness and defective ...
Kai Chen, Ziyin Guan, Hanwei Jin, Muladili Aihemaiti, Rong Mou, Mengting Yu, Yanhua Hu, Liujun Jiang, Xuliang Wang, Hao Yang, Ting Chen, Yao Lu, Hongkun Zhang, Qingbo Xu, Weidong Li   +14 more
wiley   +1 more source

Piloting lymphoedema management for lymphatic filariasis: experiences and perceptions of patients and stakeholders from Kwale county, coastal Kenya. [PDF]

BMC Public Health
Kepha S, Were V, Okello G, Okoyo C, Omondi WP, Njomo DW.   +5 more
europepmc   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, EarlyView.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source