Results 91 to 100 of about 105,489 (333)

The Role of Lymphatic Endothelial Cells in T Cell Tolerance [PDF]

, 2017
The adaptive immune response can recognize a tremendous variety of antigens. Therefore, robust self-tolerance mechanisms are critical to prevent autoimmunity. Tolerance begins during T cell development in the thymus and continues in lymph nodes. Recently, we demonstrated that lymphatic endothelial cells (LEC) transcribe tyrosinase mRNA and present ...
openaire   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

An acidic microenvironment promotes lymphatic metastasis of melanoma by Thy-1 in endothelial cells and integrin αvβ3 in tumor cells

Discover Oncology
Melanoma tissues exhibit an acidic microenvironment compared with that of surrounding normal tissues. However, the effects of acidic conditions on the lymphatic metastasis, a crucial prognostic factor for patients with melanoma, are unclear.
Akiya Ibe, Masako Nakanishi, Kurumi Higashimoto, Yasuteru Muragaki, Shogo Ehata   +4 more
doaj   +1 more source

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer [PDF]

, 2019
Aims Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations.
Bartosch, Carla, Bosse, Tjalling, Genestie, Catherine, Lax, Sigurd F, McCluggage, W Glenn, Nout, Remi, Oosting, Jan, Peters, Elke E M, Singh, Naveena, Smit, Huub C S H, Smit, Vincent T H B M, Van de Vijver, Koen   +11 more
core   +2 more sources

Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome [PDF]

Journal of Cellular and Molecular Medicine, 2016
AbstractAlthough lymphatic neovascularization may be a key feature of chronic inflammation, it is almost unexplored in primary Sjögren's syndrome (pSS). A recent study revealed a pro‐lymphangiogenic function of interleukin (IL)‐17, a leading player in pSS pathogenesis.
Alunno, Alessia, Ibba, Lidia, Bistoni, Onelia, Rosa, Irene, Caterbi, Sara, Gerli, Roberto, Manetti, Mirko   +6 more
openaire   +6 more sources

Molecular Profiling of Lymphatic Endothelial Cell Activation In Vitro

International Journal of Molecular Sciences, 2023
The lymphatic vascular system plays a key role in cancer progression. Indeed, the activation of lymphatic endothelial cells (LECs) through the lymphangiogenic process allows for the formation of new lymphatic vessels (LVs) that represent the major route for the dissemination of solid tumors.
Marta Turati, Gianluca Mattei, Alessia Boaretto, Alberto Magi, Maura Calvani, Roberto Ronca   +5 more
openaire   +3 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

A Review of Mathematical Models for the Formation of\ud Vascular Networks [PDF]

, 2012
Mainly two mechanisms are involved in the formation of blood vasculature: vasculogenesis and angiogenesis. The former consists of the formation of a capillary-like network from either a dispersed or a monolayered population of endothelial cells ...
Bell, C. G., Preziosi, L., Scianna, M.
core