Results 91 to 100 of about 111,283 (329)

PMab-235: A monoclonal antibody for immunohistochemical analysis against goat podoplanin

Heliyon, 2019
Sensitive and specific monoclonal antibodies (mAbs) against not only human but also mouse, rat, rabbit, dog, cat, bovine, pig, and horse podoplanins (PDPNs) have been established in our previous studies.
Yoshikazu Furusawa, Shinji Yamada, Takuro Nakamura, Masato Sano, Yusuke Sayama, Shunsuke Itai, Junko Takei, Hiroyuki Harada, Masato Fukui, Mika K. Kaneko, Yukinari Kato   +10 more
doaj   +1 more source

Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium

Frontiers in Immunology, 2021
Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri, Kari Vaahtomeri, Christine Moussion, Robert Hauschild, Michael Sixt   +4 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice [PDF]

, 2013
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality.
Baldwin, H.M., Carballido, J.M., Graham, G.J., Jamieson, T., Jaritz, M., King, V., McKimmie, C.S., Nibbs, R.J.B., Pallas, K., Rot, A.   +9 more
core   +1 more source

Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells [PDF]

Molecular and Cellular Biology, 2013
One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development.
Konstantin I, Ivanov, Yan, Agalarov, Leena, Valmu, Olga, Samuilova, Johanna, Liebl, Nawal, Houhou, Hélène, Maby-El Hajjami, Camilla, Norrmén, Muriel, Jaquet, Naoyuki, Miura, Nadine, Zangger, Seppo, Ylä-Herttuala, Mauro, Delorenzi, Tatiana V, Petrova   +13 more
openaire   +2 more sources

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes

Frontiers in Microbiology, 2012
Kaposi’s Sarcoma is a highly vascularized tumor supporting large amounts of neo-angiogenesis. The major cell type in KS tumors is the spindle cell, a cell that expresses markers of lymphatic endothelium. KSHV, the etiologic agent of KS, is found in the
Terri A. DiMiao, Michael eLagunoff
doaj   +1 more source

Molecular Mechanisms Controlling Lymphatic Endothelial Junction Integrity

Frontiers in Cell and Developmental Biology, 2021
The lymphatic system is essential for lipid absorption/transport from the digestive system, maintenance of tissue fluid and protein homeostasis, and immune surveillance.
Pieter R. Norden, Tsutomu Kume
doaj   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

An acidic microenvironment promotes lymphatic metastasis of melanoma by Thy-1 in endothelial cells and integrin αvβ3 in tumor cells

Discover Oncology
Melanoma tissues exhibit an acidic microenvironment compared with that of surrounding normal tissues. However, the effects of acidic conditions on the lymphatic metastasis, a crucial prognostic factor for patients with melanoma, are unclear.
Akiya Ibe, Masako Nakanishi, Kurumi Higashimoto, Yasuteru Muragaki, Shogo Ehata   +4 more
doaj   +1 more source