Results 171 to 180 of about 111,283 (329)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway [PDF]

, 2016
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders.
Blacher, S., García-Caballero, Melissa, Medina, Miguel Ángel, Nöel, Agnes, Pauper, J., Quesada, Ana R.   +5 more
core  

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

, 2002
Tatiana V. Petrova
openalex   +1 more source

Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

, 2023
Tara Karnezis, Rae H. Farnsworth, Nicole C. Harris, Steven P. Williams, Carol Caesar, David J. Byrne, Prad Herle, Maria L. Macheda, Ramin Shayan, You‐Fang Zhang, Sezer Yazar, Simon J. Takouridis, Craig Gérard, Stephen B. Fox, Marc G. Achen, Steven A. Stacker   +15 more
openalex   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Cardiac lymphatic vessels, transport, and healing of the infarcted heart [PDF]

, 2017
Huang, Li-Hao, Lavine, Kory J, Randolph, Gwendalyn J   +2 more
core   +2 more sources

Measurement of Nitric Oxide Production from Lymphatic Entothelial Cells Under Mechanical Stimuli [PDF]

, 2013
The lymphatic system plays an important role in fluid and protein balance within the interstitial spaces. Its dysfunction could result in a number of debilitating diseases, namely lymphedema.
Jafarnejad, Mohammad 1987-
core   +1 more source

Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells [PDF]

, 2019
Beth A. Jirón Tamburini, Jeffrey M. Finlon, Austin E. Gillen, Michael Kriss, Kent Riemondy, Rui Fu, Ronald P. Schuyler, Jay R. Hesselberth, Hugo R. Rosen, Matthew A. Burchill   +9 more
openalex   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source