Results 171 to 180 of about 105,489 (333)

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]

, 2019
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G, Gray, Elizabeth E, Laidlaw, Brian J, Ramírez-Valle, Francisco, Zhang, Yang   +4 more
core   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow, CCL27-Expressing Lymphatic Endothelial Cells [PDF]

, 2008
Nikolaus Wick, Daniela Haluza, Elisabeth Gurnhofer, Ingrid Raab, Marie‐Theres Kasimir, Michael Prinz, Carl-Walter Steiner, Christina M. Reinisch, Anny Howorka, Pietro Giovanoli, Sabine Buchsbaum, Sigurd Krieger, Erwin Tschachler, Peter Petzelbauer, Dontscho Kerjaschki   +14 more
openalex   +1 more source

Cardiac lymphatic vessels, transport, and healing of the infarcted heart [PDF]

, 2017
Huang, Li-Hao, Lavine, Kory J, Randolph, Gwendalyn J   +2 more
core   +2 more sources

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu   +16 more
wiley   +1 more source

Activation of Akt through gp130 Receptor Signaling Is Required for Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphatic Reprogramming of Endothelial Cells [PDF]

, 2008
Valerie Morris, Almira S. Punjabi, Michael Lagunoff   +2 more
openalex   +1 more source

The role of lymphatic endothelial cell metabolism in lymphangiogenesis and disease

Frontiers in Cardiovascular Medicine
Lymphatic endothelial cells (LECs) line lymphatic vessels, which play an important role in the transport of lymph fluid throughout the human body. An organized lymphatic network develops via a process termed “lymphangiogenesis.” During development, LECs respond to growth factor signaling to initiate the formation of a primary lymphatic vascular network.
Summer Simeroth, Summer Simeroth, Pengchun Yu, Pengchun Yu   +3 more
openaire   +3 more sources

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Angiopoietin-2 Exocytosis Is Stimulated by Sphingosine-1-Phosphate in Human Blood and Lymphatic Endothelial Cells [PDF]

, 2008
Cholsoon Jang, Young Jun Koh, Nam Kyu Lim, Hyun Jung Kang, Duk Hoon Kim, Sung Kwang Park, Gyun Min Lee, Choon Ju Jeon, Gou Young Koh   +8 more
openalex   +1 more source

Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells. [PDF]

PLoS One, 2023
Sigmund EC, Bauer A, Jakobs BD, Tatliadim H, Tacconi C, Thelen M, Legler DF, Halin C, Halin C.   +8 more
europepmc   +1 more source