KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley +1 more source
The Interstitial Fluid Compartment: Still Unrecognized or Biophysically Well Described? [PDF]
Negrini D, Miserocchi G.
europepmc +1 more source
ABSTRACT Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a major complication in women with epithelial ovarian cancer (EOC). We aimed to develop and externally validate an early postoperative risk score to identify EOC patients at increased risk of VTE after debulking surgery.
Qiu‐Lin Cui +6 more
wiley +1 more source
Dermatomal Microcycstic Lymphatic Malformation: A Case Report of an Unusual Presentation. [PDF]
Alzhrani G +5 more
europepmc +1 more source
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
He Wang +4 more
wiley +1 more source
Oral Hobnail Hemangioma of the Maxillary Labial Mucosa: Clinicopathologic Findings of a Rare Case. [PDF]
Dinç K, Yaşar F, Çelik M.
europepmc +1 more source
Orbital Lymphatic Malformations Are Associated With Intracranial Vascular Anomalies
In this retrospective series, all seven patients with orbital lymphatic malformations had intracranial vascular anomalies consistent with cerebrofacial venous metameric syndrome and hotspot PIK3CA variants identified through tissue‐based sequencing. Five patients treated with alpelisib experienced symptom improvement within 6 months.
Kelsey A. Loy +11 more
wiley +1 more source
From Somatic Driver to Molecular Therapy in Retinal, Choroidal and Periocular Vascular Disease: Mosaicism, Targetable Pathways and Ocular Toxicity. [PDF]
Adamski W.
europepmc +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Editorial: Insights in vascular physiology: 2025. [PDF]
Martinez-Lemus LA, Garland C, Braun AP.
europepmc +1 more source

