Results 101 to 110 of about 138,784 (286)

A Randomized Trial of a New Triple Drug Treatment for Lymphatic Filariasis

New England Journal of Medicine, 2018
BACKGROUND The World Health Organization has targeted lymphatic filariasis for global elimination by 2020 with a strategy of mass drug administration. This trial tested whether a single dose of a three‐drug regimen of ivermectin plus diethylcarbamazine ...
C. King, James Suamani, Nelly Sanuku, Yao-Chieh Cheng, Samson Satofan, B. Mancuso, L. Robinson, P. Siba, G. Weil, J. Kazura   +9 more
semanticscholar   +1 more source

Evaluating context-specific evidence-based quality improvement intervention on lymphatic filariasis mass drug administration in Northern Ghana using the RE-AIM framework

Tropical Medicine and Health, 2021
Background Over a decade of implementing a global strategy to eliminate lymphatic filariasis in Ghana through mass drug administration, the disease is still being transmitted in 11 districts out of an initial 98 endemic districts identified in 2000.
Alfred Kwesi Manyeh, Tobias Chirwa, Rohit Ramaswamy, Frank Baiden, Latifat Ibisomi   +4 more
doaj   +1 more source

An improved mosquito electrocuting trap that safely reproduces epidemiologically relevant metrics of mosquito human-feeding behaviours as determined by human landing catch [PDF]

, 2016
Background: Reliable quantification of mosquito host—seeking behaviours is required to determine the efficacy of vector control methods. For malaria, the gold standard approach remains the risky human landing catch (HLC).
Ferguson, Heather M., Govella, Nicodem J., Johnson, Paul C.D., Killeen, Gerry F., Maliti, Deodatus F., Massallu, John P., Mirzai, Nosrat, Mlwale, Amos T.   +7 more
core   +3 more sources

A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines

Advanced NanoBiomed Research, Volume 5, Issue 3, March 2025.
Nanomaterial‐integrated microneedles revolutionize transdermal delivery, enabling targeted and controlled administration of therapeutics and vaccines. This review explores advancements in design, manufacturing, and applications, emphasizing enhanced drug stability, bioavailability, and patient adherence. Key preclinical and clinical findings as well as
Bwalya Angel Witika, Aaron Hutton, Pedzisai A. Makoni, Ryan F. Donnelly   +3 more
wiley   +1 more source

The Health and Economic Burdens of Lymphatic Filariasis Prior to Mass Drug Administration Programs

Clinical Infectious Diseases, 2019
Background The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000 with the goal of eliminating lymphatic filariasis (LF) as a public health problem by 2020.
C. Mathew, A. Bettis, B. Chu, M. English, E. Ottesen, M. Bradley, H. Turner   +6 more
semanticscholar   +1 more source

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency [PDF]

, 2005
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria.
Allen, Judith E, Graham, Andrea L, Lamb, Tracey J, Read, Andrew F   +3 more
core   +2 more sources

Application of microfluidic technologies in veterinary science with a view toward development of animal‐on‐a‐chip models

VIEW, Volume 6, Issue 1, February 2025.
Other than human‐based application, it is important for microfluidics technology to be integrated in the field of veterinary science. With current but limited existing studies and experience from plenty of human‐oriented microfluidics applications, microfluidics technologies will bring tremendous benefit to the welfare and healthcare of various animal ...
Qiankun Yin, Zhenxu Yang, Shin Wei Chong, Jiarong Li, Xiaochen Liu, Daniele Vigolo, Jiao Jiao Li, Paul A. Sheehy, Ken‐Tye Yong   +8 more
wiley   +1 more source

A morphological identification key to the mosquito disease vectors of the Pacific

Austral Entomology, Volume 64, Issue 1, February 2025.
Abstract An identification guide is provided for female adults of the mosquito groups, complexes or species that can be morphologically differentiated and that are likely to transmit arboviruses (e.g., dengue, Zika, chikungunya, Ross River and Japanese encephalitis) or parasites (e.g., Plasmodium spp.
Narayan Gyawali, Tanya L. Russell, Thomas R. Burkot, Gregor J. Devine   +3 more
wiley   +1 more source

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Journal of Medicinal Chemistry, 2019
A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found to be potent anti-Wolbachia antibiotics and, as such, may be useful in the treatment of filarial
R. Jacobs, C. Lunde, Y. Freund, Vincent Hernández, Xianfeng Li, Yi Xia, D. S. Carter, P. Berry, J. Halladay, F. Rock, Rianna Stefanakis, E. Easom, J. Plattner, L. Ford, K. Johnston, Darren Cook, R. Clare, A. Cassidy, Laura J. Myhill, Hayley E. Tyrer, Joanne Gamble, Ana F Guimaraes, A. Steven, F. Lenz, Alexandra Ehrens, Stefan J. Frohberger, Marianne Koschel, A. Hoerauf, M. Hübner, C. McNamara, M. Bakowski, J. Turner, M. Taylor, S. Ward   +33 more
semanticscholar   +1 more source

High frequency of mitochondrial DNA rearrangements in the peripheral blood of adults with intellectual disability

Journal of Intellectual Disability Research, Volume 69, Issue 2, Page 137-152, February 2025.
Abstract Background Mitochondrial DNA (mtDNA) rearrangements are recognised factors in mitochondrial disorders and ageing, but their involvement in neurodevelopmental disorders, particularly intellectual disability (ID) and autism spectrum disorder (ASD), remains poorly understood. Previous studies have reported mitochondrial dysfunction in individuals
B. K. Bulduk, J. Tortajada, L. Torres‐Egurrola, A. Valiente‐Pallejà, R. Martínez‐Leal, E. Vilella, H. Torrell, G. Muntané, L. Martorell   +8 more
wiley   +1 more source