Results 131 to 140 of about 709,350 (366)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma

Journal of Experimental & Clinical Cancer Research, 2009
Background To investigate the role of vascular endothelial growth factors (VEGF)-C/D and their receptor Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma.
Zhang Renhua, Zhang Shiqian, Yu Hao, Zhang Linlin   +3 more
doaj   +1 more source

An overview of the focus of the International Gap Junction Conference 2017 and Future Perspectives [PDF]

, 2018
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Kwak, Brenda R., Martin, Patricia E.
core   +2 more sources

Imaging the steps of lymphatic metastasis

The FASEB Journal, 2008
The mechanisms used by cancer cells to form lymph node metastasis are starting to be understood, with the hope of identifying treatment strategies to lower mortality due to disseminated cancer. In contrast to hematogenous metastasis in which the primary tumor has functional blood vessels for cancer cells to invade, the story for lymphatic metastasis is
openaire   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]

, 2009
Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Baur, Dorothee M., Besig, Sophie, Braun, Thomas, Hoefler, Heinz, Langer, Rupert, Perren, Aurel, Prinz, Christian, Rad, Roland, Voland, Petra   +8 more
core   +2 more sources

Periostin+cancer‐associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma

Molecular Oncology, 2020
Lymph node metastasis (LNM), a critical prognostic determinant in cancer patients, is critically influenced by the presence of numerous heterogeneous cancer‐associated fibroblasts (CAFs) in the tumor microenvironment.
Wenfei Wei, Xiaojing Chen, Luojiao Liang, Lan Yu, Xiangguang Wu, Chenfei Zhou, Zici Wang, Liangsheng Fan, Zheng Hu, L. Liang, Wei Wang   +10 more
semanticscholar   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

From Mechanisms to Treatment: A Comprehensive View of Lymphatic Metastasis in Cancer

Lymphatics
The lymphatic system, a complex and dynamic network comprising lymphatic vessels, lymph nodes (LNs), and associated lymphoid tissues, plays a pivotal role in regulating interstitial fluid balance and providing immune surveillance across the body.
Nitya Devisetti, Pushti Shah, Farrah C. Liu   +2 more
doaj   +1 more source

Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis

Scientific Reports, 2018
Lymphatic metastasis is known to contribute to worse prognosis of biliary tract cancer (BTC). Recently, sphingosine-1-phosphate (S1P), a bioactive lipid mediator generated by sphingosine kinase 1 (SPHK1), has been shown to play an important role in ...
Yuki Hirose, Masayuki Nagahashi, Eriko Katsuta, Kizuki Yuza, Kohei Miura, Jun Sakata, Takashi Kobayashi, Hiroshi Ichikawa, Yoshifumi Shimada, Hitoshi Kameyama, Kerry-Ann McDonald, Kazuaki Takabe, Toshifumi Wakai   +12 more
doaj   +1 more source