Parallels of Resistance between Angiogenesis and Lymphangiogenesis Inhibition in Cancer Therapy
Cells, 2020 Metastasis is the primary cause of cancer-related mortality. Cancer cells primarily metastasize via blood and lymphatic vessels to colonize lymph nodes and distant organs, leading to worse prognosis.
Dennis Jones
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An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]
, 2011 Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized by intricate interplay of molecular interactions.
arxiv +1 more source
Current status of sentinel lymph node biopsy in solid malignancies [PDF]
, 2004 Lymphatic mapping and sentinel lymph node biopsy were first reported in 1977 by Cabanas for penile cancer. Since that time, the technique has become rapidly assimilated into clinical practice.
Goyal, Amit, Mansel, Robert E
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VEGF-D(ilated) Lymphatics as Gateways to Metastasis [PDF]
Cancer Cell, 2012 VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of new intra/peritumoral capillary lymphatics. In this issue of Cancer Cell, Karnezis and colleagues challenge this notion and demonstrate that tumor-derived VEGF-D promotes metastasis by causing prostaglandin-dependent dilation of collecting lymphatics outside of the ...
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B Lymphocytes Promote Lymphogenous Metastasis of Lymphoma and Melanoma
Neoplasia: An International Journal for Oncology Research, 2011 The prognosis of patients with many types of cancers correlates with the degree of metastasis to regional lymph nodes (LNs) and vital organs. However, the mechanisms and route of cancer cell metastasis are still unclear.
Alanna Ruddell +4 more
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Microwave lymphedema assessment using deep learning with contour assisted backprojection [PDF]
We present a method for early detection of lymphatic fluid accumulation in lymphedema patients based on microwave imaging of the limb volume across an air gap. The proposed algorithm uses contour information of the imaged limb surface to approximate the wave propagation velocity locally to solve the eikonal equation for implementing the adjoint imaging
arxiv +1 more source
VEGF-C is associated with lymphatic status and invasion in oral cancer [PDF]
, 2019 Background: Nodal metastasis is a major prognostic indicator for oral squamous cell carcinoma (OSCC) progression. Recently, it has been revealed that lymphangiogenic growth factor VEGF-C and its receptor Flt-4 play an important role for invasion and ...
Kudo, Yasusei +5 more
core
Cancer associated fibroblasts: the architects of stroma remodelling [PDF]
, 2018 Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of soluble factors, ECM components and extracellular vesicles. While in physiological conditions this makes fibroblasts master regulators of tissue homeostasis and ...
Acerbi +178 more
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Imaging the steps of lymphatic metastasis
The FASEB Journal, 2008 The mechanisms used by cancer cells to form lymph node metastasis are starting to be understood, with the hope of identifying treatment strategies to lower mortality due to disseminated cancer. In contrast to hematogenous metastasis in which the primary tumor has functional blood vessels for cancer cells to invade, the story for lymphatic metastasis is
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Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression [PDF]
, 2016 Hypoxia-inducible factor-1α (HIF-1α) mediates the response to hypoxia or other stimuli, such as growth factors, including endothelin-1 (ET-1), to promote malignant progression in numerous tumors.
Bagnato, Anna +6 more
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