Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma
The Journal of Pathology, 2009 AbstractThe invasion of lymphatic vessels by colorectal cancer (CRC) and its subsequent spread to draining lymph nodes is a key determinant of prognosis in this common and frequently fatal malignancy. Although tumoural lymphangiogenesis is assumed to contribute to this process, review of the current literature fails to support any notion of a simple ...
Royston, D, Jackson, D
openaire +4 more sources
Quantification of the underlying mechanisms and relationship among cancer, metastasis and differentiation/development [PDF]
arXiv, 2018 Recurrence and metastasis have been regarded as two of the greatest obstacles for curing cancer. Cancer stem cell (CSC) have been found. They contribute to cancer development with the distinct feature of recurrence and resistance to the popular treatments such as drugs and chemotherapy.
arxiv
Neoplasia: An International Journal for Oncology Research, 2010 The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature.
Robert B. Rebhun +5 more
doaj +1 more source
Novel digital tissue phenotypic signatures of distant metastasis in colorectal cancer [PDF]
arXiv, 2018 Distant metastasis is the major cause of death in colorectal cancer (CRC). Patients at high risk of developing distant metastasis could benefit from appropriate adjuvant and follow-up treatments if stratified accurately at an early stage of the disease.
arxiv
A Robust and Effective Approach Towards Accurate Metastasis Detection and pN-stage Classification in Breast Cancer [PDF]
arXiv, 2018 Predicting TNM stage is the major determinant of breast cancer prognosis and treatment. The essential part of TNM stage classification is whether the cancer has metastasized to the regional lymph nodes (N-stage). Pathologic N-stage (pN-stage) is commonly performed by pathologists detecting metastasis in histological slides.
arxiv
Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence. [PDF]
, 2016 We have previously developed a genetically-engineered GFP-expressing telomerase-dependent adenovirus, OBP-401, which can selectively illuminate cancer cells.
Bouvet, Michael +9 more
core +2 more sources
On tumor development: fractional transport approach [PDF]
arXiv, 2004 A growth of malignant neoplasm is considered as a fractional transport approach. We suggested that the main process of the tumor development through a lymphatic net is fractional transport of cells. In the framework of this fractional kinetics we were able to show that the mean size of main growth is due to subdiffusion, while the appearance of ...
arxiv
Pigmented melanoma cell migration study on murine syngeneic B16F10 melanoma cells or tissue transplantation models [PDF]
, 2019 Melanoma is a lethal form of skin cancer with poor prognosis, especially due to the early metastatic feature. Recent studies have shown that the melanin pigment influences the nanomechanical properties and, therefore, the metastatic behavior of the ...
Buteică, Sandra Alice +5 more
core +1 more source
Ech1 is a potent suppressor of lymphatic metastasis in hepatocarcinoma
Biomedicine & Pharmacotherapy, 2013 We have previously demonstrated that Ech1 is involved in the lymphatic metastasis of tumors in vitro. Here, we gain an insight into the role that Ech1 is playing in Hca-F cell. The expression of Annexin A7, Gelsolin and Clic1 genes, which were also relevant to tumor lymphatic metastasis, had been inhibited due to downregulation Ech1 gene by Western ...
Rongkuan Li +9 more
openaire +3 more sources
An improved model of an actively contracting lymphatic vessel composed of several lymphangions: pumping characteristics [PDF]
arXiv, 2015 Using essentially our 2011 numerical model of a multi-lymphangion segment of a collecting lymphatic vessel, but augmented by inclusion of a refractory period and definition of a mid lymphangion pressure, we explore the effect of several parameters on the form of pump function curves.
arxiv