Results 41 to 50 of about 104,618 (343)

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +3 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma

OncoImmunology, 2018
Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response.
Natacha Bordry, Maria A. S. Broggi, Kaat de Jonge, Karin Schaeuble, Philippe O. Gannon, Periklis G. Foukas, Esther Danenberg, Emanuela Romano, Petra Baumgaertner, Manuel Fankhauser, Noémie Wald, Laurène Cagnon, Samia Abed-Maillard, Hélène Maby-El Hajjami, Timothy Murray, Kalliopi Ioannidou, Igor Letovanec, Pu Yan, Olivier Michielin, Maurice Matter, Melody A. Swartz, Daniel E. Speiser   +21 more
doaj   +1 more source

Impact of Lymphangiogenesis on Cardiac Remodeling After Ischemia and Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Lymphatic vessels interconnect with blood vessels to form an elaborate system that aids in the control of tissue pressure and edema formation. Although the lymphatic system has been known to exist in a heart, little is known about the role the
Yuuki Shimizu, Rohini Polavarapu, Kattri‐Liis Eskla, Yvanna Pantner, Chad K. Nicholson, Masakazu Ishii, Daniel Brunnhoelzl, Rohit Mauria, Ahsan Husain, Nawazish Naqvi, Toyoaki Murohara, John W. Calvert   +11 more
doaj   +1 more source

Index [PDF]

, 1941
PURPOSE. To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas. METHODS.
Bourghardt Peebo, Beatrice, Fagerholm, Per, Lagali, Neil, Traneus-Rockert, Catharina   +3 more
core   +2 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction

Frontiers in Immunology
Myocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic vessels are ...
Zhihua Yang, Zhihua Yang, Zeyu Zhang, Zeyu Zhang, Shaoling Feng, Shaoling Feng, Xujin Ning, Xujin Ning, Liuli Guo, Yijia Du, Yijia Du, Shuai Wang, Shuai Wang, Xianliang Wang, Xianliang Wang, Jingyuan Mao, Jingyuan Mao   +16 more
doaj   +1 more source

Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5

OncoImmunology, 2019
Tumor-associated blood vessels and lymphatics are abnormal and dysfunctional. These are hallmarks of the tumor microenvironment, which has an immunosuppressive nature, such as through hypoxia. Treatment with anti-death receptor5 (DR5) monoclonal antibody
Yoko Tsukita, Tatsuma Okazaki, Satoru Ebihara, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Taizou Hirano, Hisatoshi Sugiura, Tsutomu Tamada, Nobuyuki Tanaka, Yasufumi Sato, Hideo Yagita, Masakazu Ichinose   +12 more
doaj   +1 more source

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

eLife, 2017
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich   +10 more
doaj   +1 more source