ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows +19 more
wiley +1 more source
Decoding NOTCH1: From T-Cell Development Guardian to Driver of Pediatric T-Cell Lymphoblastic Lymphoma. [PDF]
Leijnen F, Lammens T.
europepmc +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Risk Factors Influencing Survival in T-Cell Lymphoblastic Lymphoma and T-Cell Acute Lymphoblastic Leukemia. [PDF]
Kim TY +12 more
europepmc +1 more source
Abstract Few studies have evaluated the impact of organ‐specific tumor microenvironments (TMEs) on clinical outcomes in diffuse large B‐cell lymphoma (DLBCL). This study investigated potential molecular markers, the immune cell composition within the TME, and their associations with clinical outcomes in patients with primary intestinal DLBCL (PI‐DLBCL).
Wei‐Li Ma +11 more
wiley +1 more source
Case Report: Rare pleural effusion-a case of B-lymphoblastic lymphoma presenting with pleural effusion and diagnostic challenges. [PDF]
Lu F +5 more
europepmc +1 more source
Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study
ABSTRACT Cancer care is often complicated by coagulopathy leading to thrombosis and bleeding. While venous thromboembolism (VTE) has been extensively studied, bleeding remains an underestimated threat. To address this knowledge gap, we leveraged the Epic Cosmos database to determine the impact of cancer‐associated clinically relevant bleeding (CRB) in ...
Ming Y. Lim +11 more
wiley +1 more source
Paediatric lymphoblastic lymphoma: a national review of 20 years of clinical and biological data in Ireland. [PDF]
Trinquand A +9 more
europepmc +1 more source
ABSTRACT Despite significant progress in chronic GVHD therapies, challenges remain in understanding pleomorphic phenotypes and varying responses to treatment. The aim of this study was to identify predictors of treatment response. We conducted a prospective, observational cohort study of patients beginning first‐, second‐, or third‐line systemic ...
Betty K. Hamilton +11 more
wiley +1 more source
Transfusion-Related Iron Overload in Children With Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: Addressing an Overlooked Treatment Complication. [PDF]
Matijasic Stjepovic N +7 more
europepmc +1 more source

