Results 131 to 140 of about 99,740,226 (294)

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

The C-reactive protein–albumin–lymphocyte index as a predictor of new-onset atrial fibrillation after ST-segment elevation myocardial infarction: A retrospective cohort study

Journal of International Medical Research
Objective New-onset atrial fibrillation is a common complication following ST-segment elevation myocardial infarction and is associated with poor prognosis.
Mengchao Jin, Siliang Peng, Kun Liu, Jiayu Yin, Feng Li, Yang Zhang   +5 more
doaj   +1 more source

Diagnostic possibilities of composite inflammatory indexes in purulent-septic surgical diseases

Вестник анестезиологии и реаниматологии
Introduction. The emergence of new composite (incorporated, combined, aggregated) indices that allow simultaneously evaluating inflammation, nutrition, and immunity is being actively studied as a risk factor for severe cardiovascular, oncological, and ...
Yu. Yu. Kiryachkov
doaj   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

The Diagnostic Accuracy of Neutrophil-to-Lymphocyte Ratio (NLR) Compared to C-Reactive Protein (CRP) in Patients with Acute Cholecystitis: A Systematic Review and Meta-Analysis

Diagnostics
Background/Objectives: Acute cholecystitis is associated with an increased risk of morbidity and mortality. Thus, early diagnosis and detection of complications are essential.
Raluca-Ioana Șerban, Isaic Alexandru, Cristi Tarta, Faur Flaviu-Ionut, Duta Ciprian, Alexandru Catalin Motofelea, Dobrescu Amadeus Emanuel   +6 more
doaj   +1 more source

Dynamic Trends of Albumin-to-C-Reactive Protein Ratio: A Prognostic Indicator in Elderly Patients with Community-Acquired Pneumonia [PDF]

Lei Miao,1,* Chen Gong,2,* Jingxian Liao,2 Chunhui Xie,2 Xiaozhu Shen,2 Yajuan Cheng1 1Department of Critical Care Medicine, The second People’s Hospital of Lianyungang, Lianyungang, 222000, People’s Republic of China; 2Department of Geriatrics ...
Liao J, Gong C, Miao L, Shen X, Xie C, Cheng Y   +5 more
core  

C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

, 2020
Objective Peripheral biomarker studies in schizophrenia are insufficient to correspond to whether inflammatory markers are trait- or state-related. The main objective of this study was to compare novel biomarkers C-reactive protein/albumin ratio (CAR ...
Balcioglu, Yasin Hasan, Kirlioglu, Simge Seren, Simge Seren Kirlioglu, Yasin Hasan Balcioglu   +3 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Prognostic role of lymphocyte-to-C reactive protein ratio in hepatocellular carcinoma (HCC): A meta-analysis of 4,006 patients

Asian Journal of Surgery, 2023
Zhengyue He, Boan Lai, Hui Jiang, Ling Yang   +3 more
doaj   +1 more source