Results 1 to 10 of about 773,144 (311)

MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction

Frontiers in Immunology, 2022
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is referred ...
François Van Laethem, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer   +6 more
doaj   +1 more source

Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis

Cell Reports
Summary: Natural killer (NK) cells are the predominant lymphocyte population in the liver. At the onset of non-alcoholic steatohepatitis (NASH), an accumulation of activated NK cells is observed in the liver in parallel with inflammatory monocyte ...
Elsa Bourayou, Thibaut Perchet, Sylvain Meunier, Hugo Bouvier, Marie-Pierre Mailhe, Evie Melanitou, Ana Cumano, Rachel Golub   +7 more
doaj   +1 more source

Polypyrimidine tract-binding proteins are essential for B cell development

eLife, 2020
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development.
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner   +5 more
doaj   +1 more source

Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice

Nature Communications, 2022
Here the authors show that a high-fat diet in pregnant mice can release silencing of the imprinted Dlk1 locus in multiple generations of offspring.
Mathew Van de Pette, Andrew Dimond, António M. Galvão, Steven J. Millership, Wilson To, Chiara Prodani, Gráinne McNamara, Ludovica Bruno, Alessandro Sardini, Zoe Webster, James McGinty, Paul M. W. French, Anthony G. Uren, Juan Castillo-Fernandez, William Watkinson, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Gavin Kelsey, Amanda G. Fisher   +19 more
doaj   +1 more source

Dynamic reorganisation of intermediate filaments coordinates early B-cell activation

Life Science Alliance, 2018
This study examines the role of vimentin, a type III intermediate filament, in B-cell function using a combination of in vitro and in vivo assays, including super-resolution microscopic techniques.
Carlson Tsui, Paula Maldonado, Beatriz Montaner, Aldo Borroto, Balbino Alarcon, Andreas Bruckbauer, Nuria Martinez-Martin, Facundo D Batista   +7 more
doaj   +1 more source

New Insights into Epigenetic Regulation of T Cell Differentiation

Cells, 2021
Immature CD4− CD8− thymocytes progress through several developmental steps in the thymus, ultimately emerging as mature CD4+ (helper) or CD8+ (cytotoxic) T cells.
Avik Dutta, Harini Venkataganesh, Paul E. Love   +2 more
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Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development

Cell Reports, 2015
Jarid2 is part of the Polycomb Repressor complex 2 (PRC2) responsible for genome-wide H3K27me3 deposition. Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony ...
David Landeira, Hakan Bagci, Andrzej R. Malinowski, Karen E. Brown, Jorge Soza-Ried, Amelie Feytout, Zoe Webster, Elodie Ndjetehe, Irene Cantone, Helena G. Asenjo, Neil Brockdorff, Thomas Carroll, Matthias Merkenschlager, Amanda G. Fisher   +13 more
doaj   +1 more source

Research-based flow cytometry assays for pathogenic assessment in the human B-cell biology of gene variants revealed in the diagnosis of inborn errors of immunity: a Bruton’s tyrosine kinase case-study

Frontiers in Immunology, 2023
IntroductionInborn errors of immunity (IEI) are an expanding group of rare diseases whose field has been boosted by next-generation sequencing (NGS), revealing several new entities, accelerating routine diagnoses, expanding the number of atypical ...
L. del Pino-Molina, L. del Pino-Molina, L. Y. Bravo Gallego, L. Y. Bravo Gallego, Y. Soto Serrano, K. Reche Yebra, J. Marty Lobo, B. González Martínez, M. Bravo García-Morato, M. Bravo García-Morato, M. Bravo García-Morato, R. Rodríguez Pena, R. Rodríguez Pena, R. Rodríguez Pena, M. van der Burg, E. López Granados, E. López Granados, E. López Granados   +17 more
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Ezh2 Regulates Activation-Induced CD8+ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression

Frontiers in Immunology, 2018
Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8+ T cells to differentiate to effector and memory cells.
Guobing Chen, Kalpana Subedi, Sayantan Chakraborty, Alexie Sharov, Jian Lu, Jaekwan Kim, Xiaofan Mi, Robert Wersto, Myong-Hee Sung, Nan-ping Weng   +9 more
doaj   +1 more source

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Nature Communications, 2017
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner   +5 more
doaj   +1 more source