Results 251 to 260 of about 597,213 (313)

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, EarlyView.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

Advanced Science, EarlyView.
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba, Ami Fukushi‐Kumagai, Megumi Morisaki, Ryosuke Takeuchi, Zhize Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki   +15 more
wiley   +1 more source

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

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Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in schizophrenia

Australasian Psychiatry, 2021
Objective: Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have been used as markers of inflammation in mental illness. However, these indices have not been widely used in schizophrenia research in Chinese participants.
Xiaoyu Zhu, Jia Zhou, Yu Zhu, Feng Yan, Xiaole Han, Yunlong Tan, Ran Li   +6 more
openaire   +3 more sources

T lymphocytes

The International Journal of Biochemistry & Cell Biology, 2003
T cells are major players in the adaptive immune response to pathogens. They express clonally distributed, highly polymorphic antigen receptors that enable them to recognize cell-associated antigen. Upon antigen recognition, T cells undergo clonal amplification and progressively acquire effector functions, ranging from the production of paracrine ...
FABBRI M, SMART C, PARDI , RUGGERO
openaire   +4 more sources

Enterocolic Lymphocytic Phlebitis With Lymphocytic Colitis, Lymphocytic Appendicitis, and Lymphocytic Enteritis

The American Journal of Surgical Pathology, 2004
We describe a 53-year-old man with a history of diarrhea temporally related to the use of flutamide. He developed an acute abdomen, and presented with an ileocecal intussusception due to an edematous ischemic cecum. The ischemia was due to enterocolic lymphocytic phlebitis (ELP), with numerous associated thrombi.
Shas Cacala, Cheryl L. Wright
openaire   +2 more sources

Ageing of lymphocytes and lymphocytes in the aged

Immunology Today, 2000
Abstract Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations are reviewed with reference to the importance of integrating information on cellular alterations identified in vitro with data on ...
Amiela Globerson, Rita B. Effros
openaire   +3 more sources

Lymphocyte homeostasis

Seminars in Immunology, 1997
B- and T-lymphocyte populations have an independent homeostatic regulation of resting (B and T) and activated (B) or memory (T) cell compartments. This organization may provide an efficient mechanism to ensure simultaneously a first natural barrier of protection against common pathogens, the maintenance of immunological T-cell memory and a reservoir of
Tanchot, Corinne, Rosado, Marie Manuela, Agenes, Fabien, Freitas, Antonio A., Rocha, Benedita   +4 more
openaire   +3 more sources

Lymphocytes

2002
Publisher Summary The pulmonary immune system is constantly exposed to pathogens within the inhaled air; therefore, it becomes essential for the system to determine whether an antigenic molecule represents a hazard or not. Under normal conditions, most infectious agents or foreign antigenic materials do not signal to the host and are processed without
AGOSTINI, CARLO, SAETTA, MARINA, SEMENZATO, GIANPIETRO CARLO   +2 more
openaire   +4 more sources

Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders

Current Medicinal Chemistry, 2022
: Major depressive disorder (MDD) and bipolar disorders (BDs), the most severe types of mood disorders (MDs), are considered as among the most disabling illnesses worldwide. Several studies suggested that inflammatory neuroinflammation might be involved in the pathophysiology of MDs while reporting increasing data on the relationships between these ...
Donatella Marazziti, Samuele Torrigiani, Manuel G. Carbone, Federico Mucci, Walter Flamini, Tea Ivaldi, Liliana Dell'Osso   +6 more
openaire   +2 more sources