Results 291 to 300 of about 1,723,798 (355)

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Association analysis between CD45 lymphocyte counts and the risk of major depressive disorder: a cross-sectional study. [PDF]

BMC Psychol
Tian J, Feng J, Li G, Xue Y, Hou Y, Wu D, Nie S, Ji Y, Ruan L, Lou Z.   +9 more
europepmc   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Can Albumin/Lymphocyte Ratio and MPV/Lymphocyte Ratio Serve as New Inflammatory Biomarkers in Patients With Hyperemesis Gravidarum? [PDF]

J Clin Lab Anal
Taşkıran D, Ay O.
europepmc   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Expression and prognostic importance of lymphocyte activation gene 3 and CD73 in advanced or metastatic hepatocellular carcinoma. [PDF]

J Int Med Res
Ayhan M, Dogan A, Keser SH, Başak K, Akdeniz N, Atci MM, Erhan SS, Arikan R, Celikel C, Turan N, Yıldırım ME, Odabas H, Yıldırım S, Laçin Ş, Kostek O.   +14 more
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Generation of effector cells from T cell subsets [PDF]

, 1979
Koszinowski, Ulrich H., Simon, M. M.
core  

Risk Factors and Predictive Value of Interleukin-6 and Lymphocyte Count in Sepsis-Induced Coagulopathy: A Retrospective Study. [PDF]

Clin Appl Thromb Hemost
B S, Yang L.
europepmc   +1 more source