Results 31 to 40 of about 597,213 (313)

Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions

Frontiers in Cell and Developmental Biology, 2020
Dynamic localization of receptors and signaling molecules at the plasma membrane and within intracellular vesicular compartments is crucial for T lymphocyte sensing environmental cues, triggering membrane receptors, recruiting signaling molecules, and ...
Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Andrés Alcover, Vincenzo Di Bartolo   +4 more
doaj   +1 more source

Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the β-selection checkpoint

Cell Reports, 2021
Summary: T lymphocyte differentiation in the steady state is characterized by high cellular turnover whereby thymocytes do not self-renew. However, if deprived of competent progenitors, the thymus can temporarily maintain thymopoiesis autonomously.
Rafael A. Paiva, António G.G. Sousa, Camila V. Ramos, Mariana Ávila, Jingtao Lilue, Tiago Paixão, Vera C. Martins   +6 more
doaj   +1 more source

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor [PDF]

, 2018
derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focussed on
A Augello, AJ Nauta, AJ Poncelet, AJ White, AS Boyd, B Hegyi, B Nadal-Ginard, C Basso, C Boriesson, C Liang, CH Chen, CY Xiao, D Carrade, D Pinheiro, DR Davis, DY Nah, E Ingulli, EM Oxford, G Couto de, G Wess, G Wess, GO Ramirez-Yañez, H Kanazawa, H Takeyama, I Chimenti, JA Dixon, JG Bartolucci, JM Angles, JW Kang, K Blanc Le, K Malliaras, K Malliaras, K Sato, KM Meurs, L Cambier, L Grigorian-Shamagian, L Lauden, L Öberg, LC Dutton, LJ Kennedy, M Haidar, MA Aminzadeh, MD Nicola, ME Bernardo, ME Campian, MM Duffy, MT Hensley, MT Hensley, N Kvirkvelia, O Campuzano, P Ross, PV Johnston, Q Guan, R Gallet, R Meisel, R Ramasamy, RR Makkar, S Aggarwal, S Simpson, SJ Jansen of Lorkeers, SR Houser, ST Lee, T Maślanka, TL Lynch, TS Li, WS Lee, Y Ding, Y Sun, YC Hsueh, Z Yan   +69 more
core   +2 more sources

MYC’s Fine Line Between B Cell Development and Malignancy

Cells, 2020
The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of
Oriol de Barrios, Ainara Meler, Maribel Parra   +2 more
doaj   +1 more source

A randomised trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients: the UK-Vanguard Study [PDF]

, 2006
Objective: The objective of the trial was to evaluate in a pilot setting the safety and efficacy of interleukin-2 (IL-2) therapy when used without concomitant antiretroviral therapy as a treatment for HIV infection.
Abrams, Ann Sullivan, Carr, Carr, Carr, Christian Herzmann, Clive Loveday, Connelly, Crespo-Fierro, Davey, Davey, Davey, Dewar, Emery, Emery, Emery, George Janossy, H. Clifford Lane, Handan Wand, Jorge A Tavel, Kovacs, Kovacs, Lederman, Levy, Lisa Fosdick, Losso, Margaret A Johnson, Mark Nelson, Martin Fisher, Matthews, Mercolino, Mike Youle, Palella, Pillay, Pozniak, Richard T Davey, Ruxrungtham, Sean Emery, Sereti, Sereti, Smith, Stein, Urdea, Verbeke, Yeni   +44 more
core   +2 more sources

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Cell Reports, 2017
T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells ...
Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen   +6 more
doaj   +1 more source

Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states

Nature Communications, 2021
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood.
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn   +7 more
doaj   +1 more source

Phosphomannosyl receptors may participate in the adhesive interaction between lymphocytes and high endothelial venules. [PDF]

, 1984
Normal and malignant lymphocytes can migrate from the bloodstream into lymph nodes and Peyer's patches. This process helps distribute normal lymphocytes throughout the lymphoid system and may provide a portal of entry for circulating malignant cells.
Rosen, SD, Stoolman, LM, Tenforde, TS
core   +1 more source

RNA editing generates cellular subsets with diverse sequence within populations

Nature Communications, 2016
RNA editing rate detected from bulk RNA-seq data can vary widely. Here, by constructing a hierarchical Bayesian model, the authors report substantial variance in editing signatures detected by RNA-seq data from both single cells and a cognate bulk sample.
Dewi Harjanto, Theodore Papamarkou, Chris J. Oates, Violeta Rayon-Estrada, F. Nina Papavasiliou, Anastasia Papavasiliou   +5 more
doaj   +1 more source

Can follicular helper T cells be targeted to improve vaccine efficacy? [version 1; referees: 3 approved]

F1000Research, 2016
The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting ...
Michelle A. Linterman, Danika L. Hill
doaj   +1 more source