Results 81 to 90 of about 944,351 (214)

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Nature Communications, 2017
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner   +5 more
doaj   +1 more source

Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells

Stem Cell Reports, 2015
Self-renewal potential and multipotency are hallmarks of a stem cell. It is generally accepted that acquisition of such stemness requires rejuvenation of somatic cells through reprogramming of their genetic and epigenetic status.
Tomokatsu Ikawa, Kyoko Masuda, Mirelle J.A.J. Huijskens, Rumi Satoh, Kiyokazu Kakugawa, Yasutoshi Agata, Tomohiro Miyai, Wilfred T.V. Germeraad, Yoshimoto Katsura, Hiroshi Kawamoto   +9 more
doaj   +1 more source

JC virus-DNA detection is associated with CD8 fffector accumulation in peripheral blood of patients with multiple sclerosis under natalizumab treatment, independently from JC virus serostatus [PDF]

, 2018
Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus ...
Anzivino, Elena, Ciardi, Maria R., Cortese, Antonio, D’Abramo, Alessandra, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Lichtner, Miriam, Mastroianni, Claudio M., Morreale, Manuela, Oliva, Alessandra, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Rodio, Donatella Maria, Vullo, Vincenzo, Zingaropoli, Maria A.   +16 more
core   +3 more sources

Separation of lymphocytes by electrophoresis under terrestrial conditions and at zero gravity [PDF]

Electrophoretic mobility (EPM) of human peripheral lymphocytes were examined with the following objectives: To determine differences in EPM of lymphocytes under immuno-stimulated and immuno-suppressed states.
Rubin, A. L.
core   +1 more source

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes [PDF]

, 1984
Two cloned repetitive DNA probes, pXBR and CY1, which bind preferentially to specific regions of the human X and Y chromosome, respectively, were used to study the distribution of the sex chromosomes in human lymphocyte nuclei by in situ hybridization ...
C. R. M�ller, CR M�ller, DE Comings, F Pera, F Vogel, G. A. Rappold, GA Rappold, GA Rappold, H-D Hager, H. D. Hager, JR Gosden, K. E. Davies, L Avivi, L Hens, L Hens, LM Kunkel, M Schmid, M Spaeter, MD Bennett, ML Law, P Goodfellow, PL Pearson, PS Gerhard, R Gagn�, R Lewin, T Cremer, T Cremer, T Yang, T. Cremer, T. Yang, V Kanda   +30 more
core   +1 more source

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

Nature Communications
De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour   +17 more
doaj   +1 more source

Intraepithelial Lymphocytes

Journal of Investigative Dermatology, 1980
Significant numbers of lymphocytes are normal components of most epithelia; however, despite intensive study their functional significance remains an enigma and a challenge. As in the gut epithelium, many of its lymphocytes appear to be rather than “antigen-drawn,” an indication that the tissue might be a differentiation staging post whence the ...
Seelig, Leonard, Billingham, Rupert E.
openaire   +2 more sources

Preventing laboratory-acquired Toxoplasma gondii infection: literature review and case-based post-exposure prophylaxis proposal

Frontiers in Public Health
Occupationally acquired cases of the intracellular parasite Toxoplasma gondii have been reported, even though there is uncertainty on which infection prevention measures should be implemented in such event.
Diana Póvoas, Diana Póvoas, Jocelyne Demengeot, Fernando Maltez   +3 more
doaj   +1 more source

Technical challenges of intracellular flow cytometry-based assays as a functional complement to diagnosis of signaling defects of inborn errors of immunity: PI3K pathway as a case of study

Frontiers in Immunology
BackgroundThe use of next-generation sequencing in inborn errors of immunity (IEI) has considerably increased the identification of novel gene variants, many of which are identified in patients without the described clinical phenotype or with variants of
Lucía del Pino Molina, Keren Reche Yebra, Yolanda Soto Serrano, Álvaro Clemente Bernal, Carmen L. Avendaño-Monje, J. Gonzalo Ocejo-Vinyals, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Eduardo López Granados, Eduardo López Granados, Eduardo López Granados   +11 more
doaj   +1 more source

Effect of synthetic and bovine milk conjugated linoleic acid (CLA) on immune function : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nutrition Science at Massey University [PDF]

, 1999
CLA is a collective name for a mixture of positional and geometrical isomers of linoleic acid (c-9, c-12-octadecadioenic acid) which possess conjugated double bonds.
Zhao, Hui
core