Results 101 to 110 of about 164,626 (198)

Effect of Hemoglobin, Albumin, Lymphocyte Count, and Platelet (HALP) Score on Survival of Patients with Metastatic Thyroid Cancer Treated with Tyrosine Kinase Inhibitors. [PDF]

J Clin Med
Öztop H, Hunutlu FÇ, Ekizoğlu Sİ, Gül ÖÖ, Cander S, Şahin AB.   +5 more
europepmc   +1 more source

The Relative Lymphocyte Count is Lower when the Etiological Agent in Pott Disease is Successfully Isolated. [PDF]

Rev Bras Ortop (Sao Paulo), 2023
Zanon IB, Meves R, Klautau GB.
europepmc   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Absolute lymphocyte count predicts efficacy of palbociclib in patients with metastatic luminal breast cancer. [PDF]

BMC Cancer
Kobayashi T, Nishimura M, Hosonaga M, Kizawa R, Kawai S, Aoyama Y, Ozaki Y, Fukada I, Hara F, Takano T, Ueno T.   +10 more
europepmc   +1 more source

Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions-retrospective study. [PDF]

PeerJ, 2023
Rzepakowska A, Pietruszewska W, Żurek M, Molga-Magusiak M, Leszczyński M, Niemczyk K.   +5 more
europepmc   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial. [PDF]

J Immunother Cancer
Pakola SA, Clubb JHA, Kudling TV, van der Heijden M, Jirovec E, Arias V, Haybout L, Peltola K, Alanko T, Sormunen J, Pellinen T, Taipale K, Quixabeira DCA, Kistler C, Havunen R, Sorsa S, Santos JM, Cervera-Carrascon V, Hemminki A.   +18 more
europepmc   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Effect of peripheral blood lymphocyte count on the efficacy of immunotherapy combined with TKI in the treatment of advanced liver cancer. [PDF]

Front Immunol
Zhao Q, Wang L, Fu H, Zhang Y, Xie Q.
europepmc   +1 more source