Results 181 to 190 of about 2,075,479 (379)

Treatment response and its predictors of immunosuppressive therapy in patients with severe or very severe aplastic anemia

Medicine in Drug Discovery
Severe aplastic anemia (SAA) is a hematological condition with high morbidity and mortality. Treatment with immunosuppressive agents is alternative treatment if bone marrow transplant is not available.
Thanakrit Somprasertkul, Weerayaporn Trirattanapikul, Sittichai Khamsai, Verajit Chotmongkol, Kittisak Sawanyawisuth   +4 more
doaj  

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Low peripheral blood B lymphocyte count predicts poor outcome in patients with multiple myeloma

Immunobiology
Previous evidence suggested that B lymphocytes may be involved in the progression and prognosis of multiple myeloma (MM). However, the prognostic value of peripheral B lymphocyte counts on MM before and after treatment in the novel agent era was rarely ...
Yuqi Wang, Zhongxin Zheng, Qiaoxi Kang, Linjing Cai, Shanshan Zhang, Huan Chen, Youhai Yuan, Hanzhen Zhang, Xiaolei Wei, Ru Feng, Yongqiang Wei   +10 more
doaj  

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications

Advanced Healthcare Materials, EarlyView.
Porosity governs transport mechanics in hydrogels, yet characterization in its native state remains challenging. This work harnesses particle tracking to uncover three‐dimensional pore geometric features in polyethylene glycol hydrogels. Measurements in the native state reveal pores characteristics are comparable to those obtained by cryogenic scanning
M. A. Kristine Tolentino, Eric Y. Du, Giulia Silvani, Elvis Pandzic, Kristopher A. Kilian, J. Justin Gooding   +5 more
wiley   +1 more source

Multisite Comparison of CD4 and CD8 T-Lymphocyte Counting by Single- versus Multiple-Platform Methodologies: Evaluation of Beckman Coulter Flow-Count Fluorospheres and the tetraONE System

, 2000
Keith A. Reimann, Maurice R.G. O’Gorman, John Spritzler, Cynthia L. Wilkening, Daniel E. Sabath, Karen M. Helm, Donald E. Campbell   +6 more
openalex   +3 more sources

Lymphocyte Subset Counts During the Course of Community-Acquired Pneumonia: Evolution According to Age, Human Immunodeficiency Virus Status, and Etiologic Microorganisms

, 1996
B. Fantin, Véronique Joly, Carole Elbim, J.‐L. Golmard, Marie‐Anne Pocidalo, P.Krishna Veni, C Carbon   +6 more
openalex   +1 more source

FTV 720A mediates reduction of lymphocyte counts in human renal allograft recipients by an apoptosis-independent mechanism [PDF]

, 2000
Torsten Böhler, Johannes Waiser, M. Schütz, Markus Friedrich, R. Schötschel, Simone Reinhold, Robert Schmouder, Klemens Budde, H.-H. Neumayer   +8 more
openalex   +1 more source

Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers

Advanced Healthcare Materials, EarlyView.
The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao, Zheng Zhang, Xincai Wu, Yanwei Chen, Wenjun Li, Jiayan Bao, Xin Zhang, Baoding Chen   +7 more
wiley   +1 more source

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source