Results 161 to 170 of about 1,450,283 (404)

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

Doubly Robust Fusion of Many Treatments for Policy Learning [PDF]

arXiv
Individualized treatment rules/recommendations (ITRs) aim to improve patient outcomes by tailoring treatments to the characteristics of each individual. However, when there are many treatment groups, existing methods face significant challenges due to data sparsity within treatment groups and highly unbalanced covariate distributions across groups.
arxiv  

A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia [PDF]

arXiv, 2018
Immunotherapy is currently regarded as the most promising treatment to fight against cancer. This is particularly true in the treatment of chronic lymphocytic leukemia, an indolent neoplastic disease of B-lymphocytes which eventually causes the immune system's failure.
arxiv  

Functional analysis of human T cell subsets defined by monoclonal antibodies. II. Collaborative T-T interactions in the generation of TNP-altered-self-reactive cytotoxic T lymphocytes. [PDF]

, 1981
Steven Friedman, Stuart Hunter, O H Irigoyen, Patrick C. Kung, Gideon Goldstein, Leonard Chess   +5 more
openalex   +1 more source

Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers.

Carcinogenesis, 2010
Occupational cohort and case-control studies suggest that trichloroethylene (TCE) exposure may be associated with non-Hodgkin lymphoma (NHL) but findings are not consistent. There is a need for mechanistic studies to evaluate the biologic plausibility of
Q. Lan, Luoping Zhang, Xiaojiang Tang, M. Shen, Martyn T. Smith, Chuangyi Qiu, Yichen Ge, Z. Ji, Jun Xiong, Jian He, B. Reiss, Z. Hao, Songwang Liu, Yuxuan Xie, Weihong Guo, M. Purdue, Noé Galván, Kerry X. Xin, Wei Hu, L. B. Beane Freeman, A. Blair, Laiyu Li, N. Rothman, R. Vermeulen, Han-lin Huang   +24 more
semanticscholar   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Real-Time Cell Sorting with Scalable In Situ FPGA-Accelerated Deep Learning [PDF]

arXiv
Precise cell classification is essential in biomedical diagnostics and therapeutic monitoring, particularly for identifying diverse cell types involved in various diseases. Traditional cell classification methods such as flow cytometry depend on molecular labeling which is often costly, time-intensive, and can alter cell integrity.
arxiv  

Immunosuppressive ATS. V. Analysis of the effect of anti-thymocyte serum on T lymphocyte subsets. [PDF]

, 1982
Barry J. Zimmerman, Susan L. Swain, R W Dutton   +2 more
openalex   +1 more source

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Advanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang   +9 more
wiley   +1 more source

Circulating Lymphocyte Subsets 
in Patients with Lung Cancer and Their Prognostic Value

Chinese Journal of Lung Cancer, 2011
Background and objective Lung cancer is one of the most common malignancies. The aim of this study is to investigate the relationship between the change of lymphocyte subsets in the peripheral blood of lung cancer patients and the survival rate.
Jun LUO, Zhiqiang LING, Weimin MAO
doaj   +1 more source