Results 221 to 230 of about 1,450,283 (404)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Helper and Suppressor Activities of Lymphocyte Subsets on Antithyroglobulin Production in Vitro* [PDF]

, 1985
T. Tao, Paul A. Gatenby, Shao-Ling Leu, Hung Pham, Joseph P. Kriss   +4 more
openalex   +1 more source

Essential Roles of SATB1 in Specifying T Lymphocyte Subsets.

Cell Reports, 2017
K. Kakugawa, S. Kojo, Hirokazu Tanaka, W. Seo, T. Endo, Y. Kitagawa, Sawako Muroi, M. Tenno, N. Yasmin, Y. Kohwi, S. Sakaguchi, Terumi Kowhi-Shigematsu, I. Taniuchi   +12 more
semanticscholar   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5).

, 1987
Hui Huang, N H Jones, Jack L. Strominger, L A Herzenberg   +3 more
openalex   +1 more source

Characterization of T lymphocyte subsets with monoclonal antibodies: discovery of a distinct marker, Ly-m22, of T suppressor cells. [PDF]

, 1983
Maria Chan, N Tada, Sadao Kimura, Michael K. Hoffmann, Richard A. Miller, Osias Stutman, Ulf Hammerling   +6 more
openalex   +1 more source

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

Aggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li   +12 more
wiley   +1 more source

In vitro locomotion of allosensitized T lymphocyte clones in response to metabolites of arachidonic acid is subset specific. [PDF]

, 1986
Mark L. Jordan, Rosemary A. Hoffman, E F Debe, Richard L. Simmons   +3 more
openalex   +1 more source

Changes in lymphocyte subsets, mitogen responsiveness, and interleukin-2 production after cardiac operations

, 1989
Kouichi Hisatomi, Tadashi Isomura, Takemi Kawara, Masayasu Yamashita, Akio Hirano, Hiroaki Yoshida, Naofumi Eriguchi, Kenichi Kosuga, Kiroku Ohishi   +8 more
openalex   +1 more source