Results 41 to 50 of about 432,153 (300)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Lymphocyte subsets in normal bone marrow [PDF]

Blood, 1986
Bone marrow aspirates and biopsies from ten normal donors were stained directly with monoclonal antibodies specific for lymphocyte, monocyte, and myeloid antigens, and were analyzed by flow cytometry. To avoid cell loss, lymphocytes were not specifically isolated prior to staining.
P, Clark, D E, Normansell, D J, Innes, C E, Hess   +3 more
openaire   +3 more sources

The effects of perceived stress on biological parameters in healthcare professionals: A systematic review. [PDF]

, 2014
We synthesised evidence on biological correlates of psychological stress in hospital-based healthcare professionals, and examined whether there was evidence of consistent biological changes.
Montgomery Anthony, Panagopoulou Efharis, Vedhara Kavita, Hackshaw Lucy, Dawe Karen, McGee Hannah, Morgan Hannah   +6 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets [PDF]

, 2006
The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals.
Maurer, Konrad, Schindowski, Katharina, Frölich, Lutz, Eckert, Anne, Müller, Walter E.   +4 more
core  

Effects of multiple-dose ponesimod, a selective SIP1 receptor modulator, on lymphocyte subsets in healthy humans [PDF]

, 2016
This study investigated the effects of ponesimod, a selective SIP1 receptor modulator, on T lymphocyte subsets in 16 healthy subjects. Lymphocyte subset proportions and absolute numbers were determined at baseline and on Day 10, after once-daily ...
Greenlaw, R., Dingemanse, J., Hamid, Colleen, Jurcevic, S., Hamid, C., Juif, P.E., Dingemanse, Jasper, Greenlaw, Roseanna, Jurcevic, Stipo, D'Ambrosio, D., D’Ambrosio, Daniele, Juif, Pierre Eric   +11 more
core   +1 more source

Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma [PDF]

, 2021
INTRODUCTION: Cellular immune response to cancer is known to be of great importance for tumor control. Moreover, solid tumors influence circulating lymphocytes, which has been shown for several types of cancer.
Waidhauser, Johanna, Nerlinger, Pia, Sommer, Florian, Rank, Andreas, Schiele, Stefan, Löhr, Phillip, Märkl, Bruno, Müller, Gernot, Claus, Rainer, Arndt, Tim Tobias, Eser, Stefan, Wolf, Sebastian   +11 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19

BMC Infectious Diseases, 2021
Background The lack of knowledge regarding the pathogenesis and host immune response during SARS-CoV-2 infection has limited the development of effective treatments.
Yangli Liu, Weiping Tan, Haihong Chen, Ying Zhu, Li Wan, Ke Jiang, Yubiao Guo, Kejing Tang, Canmao Xie, Hui Yi, Yukun Kuang, Yifeng Luo   +11 more
doaj   +1 more source

Effects of Selected Prebiotics or Synbiotics Administered in ovo on Lymphocyte Subsets in Bursa of the Fabricius, Thymus, and Spleen in Non-Immunized and Immunized Chicken Broilers

Animals, 2021
The effects of in ovo-delivered prebiotics and synbiotics on the lymphocyte subsets of the lymphoid organs in non-immunized 7-day-old broiler chickens and in non-immunized, sheep red blood cells (SRBC)-immunized, and dextran (DEX)-immunized 21- and 35 ...
Marianna Szczypka, Agnieszka Suszko-Pawłowska, Maciej Kuczkowski, Michał Gorczykowski, Magdalena Lis, Artur Kowalczyk, Ewa Łukaszewicz, Dominik Poradowski, Iwona Zbyryt, Marek Bednarczyk, Tadeusz Stefaniak   +10 more
doaj   +1 more source