Results 1 to 10 of about 1,304,961 (235)

Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research

open access: yesFrontiers in Immunology, 2022
Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section.
Marion Le Rochais   +5 more
doaj   +1 more source

Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry

open access: yesFrontiers in Immunology, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais   +10 more
doaj   +1 more source

Age-related accumulation of B-1 cell progenitors in mice reflects changes in miR15a/16-1 expression and radioresistance capacity

open access: yesExperimental Hematology & Oncology, 2023
Hyperproliferative diseases such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are potentially related to some disturbance in the apoptosis pathway, specifically in B-1a cells (CD5+).
Olívia F Souza   +5 more
doaj   +1 more source

Could AMPs and B-cells be the missing link in understanding periodontitis?

open access: yesFrontiers in Immunology, 2022
Periodontal diseases are common inflammatory conditions characterized by bone loss in response to simultaneous bacterial aggression and host defenses. The etiology of such diseases is still not completely understood, however.
Vanessa Dominique Lobognon   +2 more
doaj   +1 more source

IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates

open access: yesFrontiers in Immunology, 2021
Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic stimulation, mucosal immunity remains difficult to obtain through vaccines and ...
Sandrine Logerot   +9 more
doaj   +1 more source

CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]

open access: yes, 2013
B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto   +51 more
core   +6 more sources

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

open access: yesFrontiers in Immunology, 2023
Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the
Céline Cuche   +27 more
doaj   +1 more source

Hematopoiesis: A Layered Organization Across Chordate Species

open access: yesFrontiers in Cell and Developmental Biology, 2020
The identification of distinct waves of progenitors during development, each corresponding to a specific time, space, and function, provided the basis for the concept of a “layered” organization in development.
Ramy Elsaid   +28 more
doaj   +1 more source

STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia

open access: yesJournal for ImmunoTherapy of Cancer, 2019
Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant   +14 more
doaj   +1 more source

Rheumatological features of Whipple disease

open access: yesScientific Reports, 2021
Whipple disease (WD) is a rare infectious systemic disease. Rheumatologists are at the frontline of WD diagnosis due to the early rheumatological manifestations. An early diagnosis is crucial, as usual anti-rheumatic drugs, especially TNF inhibitors, may
Alice Tison   +16 more
doaj   +1 more source

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