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Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research
Frontiers in Immunology, 2022 Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section.
Marion Le Rochais +5 more
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Frontiers in Immunology, 2023 Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais +10 more
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Experimental Hematology & Oncology, 2023 Hyperproliferative diseases such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are potentially related to some disturbance in the apoptosis pathway, specifically in B-1a cells (CD5+).
Olívia F Souza +5 more
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Could AMPs and B-cells be the missing link in understanding periodontitis?
Frontiers in Immunology, 2022 Periodontal diseases are common inflammatory conditions characterized by bone loss in response to simultaneous bacterial aggression and host defenses. The etiology of such diseases is still not completely understood, however.
Vanessa Dominique Lobognon +2 more
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IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates
Frontiers in Immunology, 2021 Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic stimulation, mucosal immunity remains difficult to obtain through vaccines and ...
Sandrine Logerot +9 more
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CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]
, 2013 B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto +51 more
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Frontiers in Immunology, 2023 Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the
Céline Cuche +27 more
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Hematopoiesis: A Layered Organization Across Chordate Species
Frontiers in Cell and Developmental Biology, 2020 The identification of distinct waves of progenitors during development, each corresponding to a specific time, space, and function, provided the basis for the concept of a “layered” organization in development.
Ramy Elsaid +28 more
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STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia
Journal for ImmunoTherapy of Cancer, 2019 Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant +14 more
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Rheumatological features of Whipple disease
Scientific Reports, 2021 Whipple disease (WD) is a rare infectious systemic disease. Rheumatologists are at the frontline of WD diagnosis due to the early rheumatological manifestations. An early diagnosis is crucial, as usual anti-rheumatic drugs, especially TNF inhibitors, may
Alice Tison +16 more
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