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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
Nature Medicine, 2015 Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic effects in solid tumors than in lymphoid malignancies.
Ignazio Caruana +2 more
exaly +2 more sources
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes [PDF]
Journal of Experimental Medicine, 1989 We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings.
S. Jonjić +4 more
semanticscholar +5 more sources
Anergy in self-directed B lymphocytes from a statistical mechanics perspective [PDF]
arXiv, 2012 The ability of the adaptive immune system to discriminate between self and non-self mainly stems from the ontogenic clonal-deletion of lymphocytes expressing strong binding affinity with self-peptides. However, some self-directed lymphocytes may evade selection and still be harmless due to a mechanism called clonal anergy.
Agliari, Elena +4 more
arxiv +3 more sources
Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research
Frontiers in Immunology, 2022 Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section.
Marion Le Rochais +5 more
doaj +1 more source
Frontiers in Immunology, 2023 Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais +10 more
doaj +1 more source
Experimental Hematology & Oncology, 2023 Hyperproliferative diseases such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are potentially related to some disturbance in the apoptosis pathway, specifically in B-1a cells (CD5+).
Olívia F Souza +5 more
doaj +1 more source
Could AMPs and B-cells be the missing link in understanding periodontitis?
Frontiers in Immunology, 2022 Periodontal diseases are common inflammatory conditions characterized by bone loss in response to simultaneous bacterial aggression and host defenses. The etiology of such diseases is still not completely understood, however.
Vanessa Dominique Lobognon +2 more
doaj +1 more source
IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates
Frontiers in Immunology, 2021 Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic stimulation, mucosal immunity remains difficult to obtain through vaccines and ...
Sandrine Logerot +9 more
doaj +1 more source
Functional exhaustion of antiviral lymphocytes in COVID-19 patients
Cellular & Molecular Immunology, 2020 In December 2019, a novel coronavirus was first reported in Wuhan, China. It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for coronavirus disease 2019 (COVID-19).
M. Zheng +7 more
semanticscholar +1 more source