Results 241 to 250 of about 745,482 (386)
Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys
Advanced Science, EarlyView.Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si +10 morewiley +1 more sourceIbrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.
New England Journal of Medicine, 2014 J. Byrd, Jennifer R. Brown, S. O'brien, J. Barrientos, N. Kay, N. Reddy, S. Coutre, C. Tam, S. Mulligan, U. Jaeger, S. Devereux, P. Barr, R. Furman, T. Kipps, F. Cymbalista, C. Pocock, P. Thornton, F. Caligaris‐cappio, T. Robak, J. Delgado, S. Schuster, M. Montillo, A. Schuh, S. de Vos, D. Gill, A. Bloor, C. Dearden, C. Moreno, Jeffrey J Jones, A. Chu, M. Fardis, J. Mcgreivy, F. Clow, D. James, P. Hillmen +34 moresemanticscholar +1 more sourceAllogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion
Advanced Science, EarlyView.This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling +8 morewiley +1 more sourceEnhanced ultrasonography detection of mucosa-associated lymphoid tissue of the liver with penetrating vessels in a tumor -case report
, 2017 Tomokazu Kawaoka, Hiroshi Aikata, Yuki Inagaki, Fumi Honda, Masahiro Hatooka, Kei Morio, Reona Morio, Tomoki Kobayashi, Yuko Nagaoki, Akira Hiramatsu, Masataka Tsuge, Michio Imamura, Yoshiiku Kawakami, Koji Arihiro, Kazuaki Chayama +14 moreopenalex +2 more sourcesIrradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils
Advanced Science, EarlyView.Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan +18 morewiley +1 more sourceMaintenance rituximab following induction R-CHOP chemotherapy in patients with composite or discordant, indolent and aggressive, B-cell non-Hodgkin lymphomas
Haematologica, 2016 Roopesh Kansara, Joseph M. Connors, Kerry J. Savage, Alina S. Gerrie, David W. Scott, Graham W. Slack, Randy D. Gascoyne, Laurie H. Sehn, Diego Villa +8 moredoaj +1 more sourceS1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
Science, 2018 Yuefeng Huang, Kairui Mao, Xi Chen, Ming-an Sun, T. Kawabe, Weizhe Li, Nicholas Usher, Jinfang Zhu, J. Urban, W. Paul, R. Germain +10 moresemanticscholar +1 more source