Results 61 to 70 of about 48,469 (263)

Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Scientific Reports, 2023
Patients with primary intestinal follicular lymphoma are often followed-up without a specific treatment, and this approach is called the “watch-and-wait approach.” However, the long-term outcomes of this patient group have not been sufficiently ...
Masaya Iwamuro, Takehiro Tanaka, Daisuke Ennishi, Kazuhiro Matsueda, Masao Yoshioka, Koji Miyahara, Chihiro Sakaguchi, Mamoru Nishimura, Teruya Nagahara, Tomohiko Mannami, Ryuta Takenaka, Shohei Oka, Masafumi Inoue, Hidetaka Takimoto, Tomoki Inaba, Sayo Kobayashi, Tatsuya Toyokawa, Hirofumi Tsugeno, Seiyuu Suzuki, Sachiko Sawada, Shouichi Tanaka, Takao Tsuzuki, Hiroyuki Okada   +22 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Plasmablastic transformation of a double hit follicular lymphoma: An emerging entity

Indian Journal of Pathology and Microbiology
Plasmablastic transformation of follicular lymphoma is very rare and has been reported in only 5 cases till date. We report a case of simultaneous identification of extranodal, soft tissue plasmablastic lymphoma in the ankle and bone marrow involvement ...
Shanaz Khodaiji, Vidisha Mahajan, Krishna Sawaimoon Satyakam, Pratibha Sudhan Kadam Amare   +3 more
doaj   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Controversies in the Treatment of Follicular Lymphoma

HemaSphere, 2020
. The overall prognosis of patients with follicular lymphoma has substantially improved over the last decades with a 10-year overall survival of around 80% for the majority of patients.
Kai Hübel, Michele Ghielmini, Marco Ladetto, Ajay K. Gopal   +3 more
doaj   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Treatment of Follicular Lymphoma

Journal of Clinical and Experimental Hematopathology, 2014
Follicular lymphoma (FL) is the most common subtype of indolent lymphomas. Several lines of evidence suggest that the prognosis of patients with FL has improved since the introduction of rituximab, although cure cannot be achieved. Although the treatment paradigm for FL has changed over the past decade with the introduction of rituximab and other ...
openaire   +3 more sources

Model‐Based Analysis with Mechanistic Insights to CAR‐T‐Cell Therapy Kinetics: Case Study with Axicabtagene Ciloleucel and Brexucabtagene Autoleucel

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin, Martin Bergstrand, Ana Ruiz‐Garcia, Simone Filosto, Rhine Shen   +4 more
wiley   +1 more source

Rapidly Progressed Primary Intestinal Follicular Lymphoma with Elevation of Soluble Interleukin-2 Receptor Levels

Case Reports in Oncological Medicine, 2014
A 62-year-old Japanese male was diagnosed with primary intestinal follicular lymphoma involving the duodenum, jejunum, and rectum without lymph node involvement.
Masaya Iwamuro, Ryuta Takenaka, Atsushi Mori, Shigeatsu Fujiki, Takayoshi Miyake, Shoji Asakura, Hiroyuki Okada, Katsuyoshi Takata, Tadashi Yoshino, Kazuhide Yamamoto   +9 more
doaj   +1 more source

The prognostic significance of the intra-follicular tumor cell proliferative rate in follicular lymphoma

Haematologica, 2007
Background and Objectives In follicular lymphoma histological grading is used to predict clinical behavior and to stratify patients for treatment.
Ad Koster, Hedwig A. Tromp, John M.M. Raemaekers, George F. Borm, Konnie Hebeda, Marius A. MacKenzie, Joannes H.J.M. van Krieken   +6 more
doaj   +1 more source