Results 61 to 70 of about 596,620 (345)

HIGH RATE OF DURABLE COMPLETE REMISSION IN FOLLICULAR LYMPHOMA AFTER CD19 CAR‐T CELL IMMUNOTHERAPY

Blood, 2019
Patients with follicular lymphoma (FL) with early relapse after initial chemoimmunotherapy, refractory disease, or histologic transformation (tFL) have limited progression-free and overall survival.
A. Hirayama, J. Gauthier, K. Hay, J. Voutsinas, Q. Wu, B. Pender, R. Hawkins, A. Vakil, R. Steinmetz, S. Riddell, D. Maloney, C. Turtle   +11 more
semanticscholar   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Contained abdominal aortic rupture secondary to follicular lymphoma invasion

Journal of Vascular Surgery Cases and Innovative Techniques, 2022
An 87-year-old woman with grade IIIb follicular lymphoma treated with rituximab had presented with nausea, emesis, and chest pain of 1 day duration. She was found to have a contained abdominal aortic rupture secondary to follicular lymphoma invasion. She
Albertina Sebastian, MD, Melissa K. Meghpara, DO, MS, Mahmoud Almadani, MD, Jennifer K. Henaghan, DO, Yiwu J. Huang, MD, Robert Y. Rhee, MD   +5 more
doaj   +1 more source

Perforated small intestine in a patient with T-cell lymphoma; a rare cause of peritonitis [PDF]

, 2016
The nontraumatic perforations of the small intestine are pathological entities with particular aspects in respect to diagnosis and treatment. These peculiarities derive from the nonspecific clinical expression of the peritonitis syndrome, and from the ...
Banu, Petrisor, Constantin, Vlad D, Nistor, Mihaela F, Popa, Florian   +3 more
core   +3 more sources

Prognostic Impact of Natural Killer Cell Count in Follicular Lymphoma and Diffuse Large B-cell Lymphoma Patients Treated with Immunochemotherapy

Clinical Cancer Research, 2019
Purpose: Natural killer (NK) cells are key effector cells for anti-CD20 monoclonal antibodies (mAb), such as obinutuzumab and rituximab. We assessed whether low pretreatment NK-cell count (NKCC) in peripheral blood or tumor tissue was associated with ...
M. Klanova, M. Oestergaard, M. Trněný, W. Hiddemann, R. Marcus, L. Sehn, U. Vitolo, A. Bazeos, V. Goede, H. Zeuner, A. Knapp, D. Şahin, Nathalie Spielewoy, C. Bolen, A. Cardona, C. Klein, J. Venstrom, T. Nielsen, G. Fingerle-Rowson   +18 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

IGH/BCL2 Status Better Predicts Clinico-Pathological Behavior in Primary Splenic Follicular Lymphoma than Histological Grade and Other Molecular Markers

Clinical Pathology, 2022
Splenic lymphoma may be primary or secondary. Primary splenic lymphoma’s are rare and usually of follicular cell origin representing
Cherian Verghese, Weihong Li, Nanuli Gvazava, Emmanouil Alimpertis, Navkirat Kahlon, Hongliu Sun, Robert Booth   +6 more
doaj   +1 more source

Follicular Lymphoma: Current Management and Novel Approaches

Journal of Modern Oncology, 2019
Clinical recommendations.
Nathan H. Fowler
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]

, 2016
Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather, Fung, Herman, Goodnow, Christopher, Horikawa, Keisuke, Jeelall, Yogeshraj, Kallies, Axel, Law, Hsei-Di, Nutt, Stephen L, Wang, James   +8 more
core   +1 more source