Results 71 to 80 of about 596,620 (345)
Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
New England Journal of Medicine, 2018 BACKGROUND Rituximab plus chemotherapy has been shown to be effective in patients with advanced‐stage, previously untreated follicular lymphoma; nevertheless, most patients will have a relapse. Combination immunotherapy with lenalidomide and rituximab is
F. Morschhauser +33 more
semanticscholar +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Case Report: Epstein-Barr virus-positive follicular lymphoma with high PD-L1 expression
Frontiers in ImmunologyBackgroundFollicular lymphoma is a common B-cell lymphoma and is classified as an indolent lymphoma, more frequently seen in middle-aged and elderly individuals.
Xue Zheng +4 more
doaj +1 more source
Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review
Molecular Cancer, 2006 Transcriptional silencing of tumor suppressor genes, associated with DNA methylation, is a common epigenetic event in hematologic malignancies. Although DNA hypermethylation of CpG islands is well described in acute leukemias and myelodysplastic ...
Montero Alberto, Hayslip John
doaj +1 more source
Managing Follicular Lymphoma in the Elderly Population
Case Reports in Medicine, 2023 Follicular lymphoma (FL) is one of the most commonly diagnosed types of indolent non-Hodgkin lymphoma (NHL). The median age of diagnosis for FL is 65 years old.
Jiao Jie Cherie Tan +2 more
doaj +1 more source
Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW. [PDF]
, 2017 Purpose: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma ...
Adams, Clare M. +3 more
core +1 more source
MicroRNAs in B cell development and malignancy [PDF]
, 2012 MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and ...
Fernando, Thilini R. +2 more
core +4 more sources
Follicular Lymphoma: Recent and Emerging Therapies, Treatment Strategies, and Remaining Unmet Needs
The Oncologist, 2019 Therapeutic advances have improved prognosis for follicular lymphoma, although the disease is still incurable. This comprehensive clinical review considers prognostic approaches and the treatment landscape for follicular lymphoma, including emerging ...
M. Matasar +11 more
semanticscholar +1 more source
Pathogenesis of follicular lymphoma [PDF]
Journal of Clinical Investigation, 2012 The hallmark t(14;18)(q32;q21) in follicular lymphoma (FL) results in constitutive overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center apoptotic program. Most tumors are characterized by recurrent secondary genetic alterations including genomic gains, losses, and mutations, some providing a growth advantage ...
Robert, Kridel +2 more
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang +10 more
wiley +1 more source