Results 61 to 70 of about 22,470,738 (286)

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain [PDF]

, 2014
BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma.
Simon D. Wagner (530388), Jamieson, Andrew G, Louise Fairall, Simon D Wagner, Wagner, Simon D, Jamieson Andrew G., Schwabe John W. R., Ko Ferrigno Paul, John W. R. Schwabe (7604093), Paul Ko Ferrigno (41085), Goult, Benjamin T., Wagner, SD, Benjamin T Goult, Evans, SE, Ford, Robert, Sian E Evans, Schwabe, JWR, Andrew G Jamieson, Fairall, Louise, Andrew G. Jamieson (530386), Wagner, Simon D., Benjamin T. Goult (173495), Sian E. Evans (7622282), Ko Ferrigno, Paul, Evans, Sian E, Robert Ford (89276), Ford Robert, Schwabe, John W R, Goult Benjamin T., P. Ko Ferrigno (7674905), Evans Sian E., Fairall, L, Fairall Louise, Schwabe, John W.R., Simon D. Wagner (7633943), John W R Schwabe, Evans, Sian E., Goult, Benjamin T, Goult, BT, Robert Ford, Jamieson, Andrew G., Louise Fairall (530385), Ko Ferrigno, P, Ford, R, John W. R. Schwabe (530387), Jamieson, AG, Wagner Simon D., Sian E. Evans (530384), Paul Ko Ferrigno, R. Ford (7674908)   +49 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

MicroRNA profiling in B cell non-Hodgkin Lymphoma : focus on the role of MYC [PDF]

, 2013
Non-Hodgkinlymfoon is een kwaadaardige vorm van kanker die uitgaat van de lymfeklieren. De ziekte wordt gekenmerkt door specifieke chromosoomafwijkingen en door afwijkende patronen van genexpressie.
Robertus, Jan Lukas,, Robertus, Jan Lukas   +1 more
core   +1 more source

Genetic background of relapsing lymphoid neoplasms : comprehensive genetic characterization of primary - relapse pairs by chromosomal copy number and mutational analysis [PDF]

, 2016
Diffuse large B-cell lymphoma (DLBCL) is the most frequent tumor of the lymphoid system. Standard first line therapy is successful in the majority of cases, however about 30% of DLBCL are either refractory to it or relapse after a period of ...
Juškevičius, Darius
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Repurposing dasatinib for diffuse large B cell lymphoma [PDF]

Proceedings of the National Academy of Sciences, 2019
To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically characterized DLBCL cell lines.
Scuoppo C, Wang J, Persaud M, Mittan SK, Basso K, Pasqualucci L, Rabadan R, Inghirami G, Grandori C, Bosch F, Dalla-Favera R   +10 more
openaire   +4 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

DNA methylation in follicular lymphoma [PDF]

, 2010
PhDFollicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival.
Ó Riain, Ciarán Liam
core   +4 more sources

Transformation of diffuse large B-cell lymphoma to lymphoblastic lymphoma

Journal of Cancer Research and Therapeutics, 2022
Transformations in diffuse large B-cell lymphoma (DLBCL) are extremely rare. Here, we are presenting a very rare case of DLBCL transforming into lymphoblastic lymphoma (LBL) diagnosed by fine-needle aspiration cytology (FNAC) and flow cytometry.
Pritika, Kushwaha, Meeta, Singh, Varuna, Mallya, Shyama, Jain, Sunita, Aggarwal, Kishore, Singh   +5 more
openaire   +2 more sources