Results 81 to 90 of about 22,470,337 (287)
Haematologica, 2015 Hepatitis C virus has been found to be associated with B-cell non-Hodgkin lymphomas, mostly marginal zone lymphomas and diffuse large B-cell lymphoma. Deregulation of signaling pathways involved in normal marginal zone development (NOTCH pathway, NF-κB ...
Luca Arcaini +23 more
doaj +1 more source
Guidelines for the management of diffuse large B‐cell lymphoma [PDF]
British Journal of Haematology, 2016 1Department of Haematology, Queen Elizabeth Hospital, Birmingham 2Department of Clinical Oncology, Christie Hospital, Manchester 3Department of Nuclear Medicine, Guys and St Thomas’ Hospitals, London 4Department of Haematology, West of Scotland Cancer Centre, Glasgow 5Department of Medical Oncology, Christie Hospital, Manchester 6Department of ...
Chaganti, Sridhar +9 more
openaire +3 more sources
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen +9 more
wiley +2 more sources
Diffuse Large B-cell Lymphoma Transformed from MALT Lymphoma Presented by Acute Abdomen
, 2014 Non-Hodgkin lymphomas constitute 1% of gastrointestinal system tumors. Lymphomas can occur from the oral cavity to the rectum. Primary gastrointestinal lymphomas are most frequent in the stomach, followed by the small and large intestines.
Muharrem KISKAÇ +4 more
core +1 more source
Molecular Pathogenesis of MALT lymphoma [PDF]
, 2011 Mucosa associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway.
core +2 more sources
Advanced Science, EarlyView.Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu +13 more
wiley +1 more source
Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
MicroRNAs in diffuse large B-cell lymphoma
Oncology Letters, 2015 The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately distinguish different subtypes and ...
Huiyun, Ni +4 more
openaire +3 more sources
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source