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This perspective article by Drs. Pileri and Falini examines the diagnosis and bio-pathology of mantle cell lymphoma in the light of the criteria of the WHO Classification and recent reports. See related articles on pages 1555, 1563 and 1595.
Stefano A. Pileri, Brunangelo Falini
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Smoldering mantle cell lymphoma [PDF]
Background Mantle cell lymphoma (MCL) is an aggressive disease, with poor prognosis and a limited survival. However, some patients with indolent MCL can survive beyond 7~10 years. These patients remain largely asymptomatic and can be in observation for a
Haige Ye +6 more
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Mantle cell lymphoma (MCL) accounts for approximately 6% of all non-Hodgkin’s lymphomas[1][1] and is characterized by the over-expression of cyclin D1 with cell cycle dysregulation, secondary to the genetic abnormality t(11;14)(q13;q32).[2][2] It often has an aggressive clinical course and ...
Michelle Furtado, Simon Rule
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Le lymphome a cellules du manteau (LCM) est une pathologie qui ne represente que 5 a 8 % des lymphomes malins non hodgkiniens. Le LCM se caracterise par la presence de la translocation reciproque entre les chromosomes 11 et 14 (11;14)(q13;q32). Celle-la induit une augmentation de l’expression de la cycline D1, aboutissant au dereglement du cycle ...
Pierre Peterlin +8 more
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Case report: Composite mantle cell lymphoma and classical Hodgkin lymphoma
Composite mantle cell lymphoma and classical Hodgkin lymphoma is very rare and the actual origin of it is still unclear. Here we reported a new case of composite mantle cell lymphoma and classical Hodgkin lymphoma and analyzed its molecular changes ...
Hongyu Wang +4 more
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The term mantle cell lymphoma (MCL) has been introduced recently, to describe lymphomas related to the primary B follicle and the mantle of the secondary lymphoid follicle. MCL forms a subset of diffuse small cleaved cell lymphomas according to the Working Formulation and correspond closely to the centrocytic lymphomas described in the Kiel ...
Stefania Pittaluga, C De Wolf-Peeters
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Purpose: Mantle cell lymphoma is a rare aggressive subtype of non-Hodgkins B cell lymphoma. It typically presents with asymptomatic monoclonal lymphocytosis, lymphadenopathy or bulky extranodal disease.
L. Small +4 more
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Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma, which is characterized by the chromosomal translocation t(11;14)(q13;q32) and overexpression of cyclin D1 in the vast majority of cases.
Milena Kohn, Lucile Bussot
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Mantle cell lymphoma presenting with severe upper gastrointestinal bleeding
. Introduction:. Although it usually involves extranodal sites such as the gastrointestinal tract in more than 80% of cases, mantle cell lymphoma is considered a rare cause of gastrointestinal bleeding, especially severe and life-threatening bleeding ...
Khaled Ali, MD +3 more
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Background There is increasing evidence that stromal cell interactions are required for the survival and drug resistance of several types of B-cell malignancies.
Daniel J. Medina +5 more
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