Results 121 to 130 of about 45,542 (206)

Artificial intelligence for risk assessment and outcome prediction in malignant haematology

British Journal of Haematology, Volume 208, Issue 1, Page 25-38, January 2026.
Machine learning models allow for dynamic and scalable risk stratification and outcome prediction. Different modalities of data such as electronic health records, patient genetics or laboratory results can be used as input. ML models autonomously select features weighing their prognostic value. Methods of model explainability in feature selection allow
Jan‐Niklas Eckardt, Wencke Walter, Jan Moritz Middeke, Torsten Haferlach   +3 more
wiley   +1 more source

Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL). [PDF]

, 2019
Angioimmunoblastic T-cell lymphoma (AITL) is one of four major subtypes of nodal peripheral T cell lymphoma, characterized by its cell of origin, the follicular helper T-cell (TFH).
Alpdogan, Onder, Gong, Jerald Z., Haverkos, Bradley M., Johnson, William T., Kartan, Saritha, Nikbakht, Neda, Porcu, Pierluigi, Sokol, Kelsey   +7 more
core   +1 more source

Role of Frailty in Assessing Eligibility for CAR T‐Cell Therapy in Haematology

European Journal of Haematology, Volume 116, Issue 1, Page 4-13, January 2026.
ABSTRACT Background and Objectives Frailty is a key consideration in determining whether a patient is robust enough for CAR T‐cell therapy; however, it should not represent a barrier to treatment. Our study aimed to describe the extent of research concerning frailty in haematology adult and paediatric patients being considered for CAR T‐cell therapy ...
Jennifer Clesham, Joan McGrory, Aoife Bannon, Deirbhle Cox, Maura Dowling   +4 more
wiley   +1 more source

Borrelia Infections Under B Cell‐Depleting Therapies: A Systematic Review of Diagnostic Challenges and Outcomes With Special Focus on Neurological Forms

European Journal of Neurology, Volume 33, Issue 1, January 2026.
Neurological infections caused by Borrelia burgdorferi sensu lato and Borrelia miyamotoi are increasingly reported in patients receiving anti‐CD20 therapies and should be considered in cases presenting with neurological symptoms and cerebrospinal fluid pleocytosis.
Emilie Cardot‐Martin, Jean Baptiste Chanson, Cédric Lenormand, Pierre Boyer, Yves Hansmann, Jean Sibilia, Benoit Jaulhac, Marc Scherlinger   +7 more
wiley   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

Processing of DNA Topoisomerase II–DNA–Protein Crosslinks Associated With Anticancer Drugs

Genes to Cells, Volume 31, Issue 1, January 2026.
Topoisomerase II (TOP2) relieving DNA torsional stress is trapped by TOP2 poisons, such as etoposide, inducing DNA double‐strand breaks (DSBs) bearing TOP2–DNA–protein crosslinks (TOP2–DPCs), which must be removed before DSB repair. This review summarizes the TOP2–DPC resolution processes mediated by multiple pathways, including proteolysis and ...
Ryo Sakasai, Kuniyoshi Iwabuchi
wiley   +1 more source

Relapsed Mantle Cell Lymphoma Presenting as “Sister Mary Joseph Nodule”

Case Reports in Medicine, 2010
The finding of umbilical metastasis has historically been called a “Sister Mary Joseph Nodule”. A few case reports of lymphoma presenting in this manner have been documented. We report a case of relapsed mantle cell lymphoma (MCL) presenting as a Sister
Jennifer E. Vaughn, Ajay K. Gopal
doaj   +1 more source

Comparative Investigation of Cytotoxic Effects of Structurally Diverse Small Molecules and In Silico Analysis of 1‐Acetyl‐4‐(4‐Hydroxyphenyl)piperazine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT This study assessed the anticancer activity of boron‐containing and structurally diverse small molecules in 4T1 breast cancer and Caco‐2 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron‐mediated bioactivity.
Azmi Yerlikaya, Emrah Tümer, Mustafa Güzel   +2 more
wiley   +1 more source

ANCA positive pauci-immune glomerulonephritis as presenting feature of mantle cell lymphoma: A case report and review of literature

Nefrología
Kidney involvement in mantle cell lymphoma is rare. We report a case of mantle cell lymphoma diagnosed after rapidly progressive glomerulonephritis with biopsy-proven paraneoplastic anti-neutrophil cytoplasmic antibody positive pauci-immune cresentic ...
Gizem Kumru, Merve Yüksel, Yasemin Geriş, Emine Selin Yıldırım, Saba Kiremitci, Işınsu Kuzu, Önder Arslan   +6 more
doaj   +1 more source

Chimeric antigen receptor T-cell therapy for aggressive B-cell lymphomas

Frontiers in Oncology
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary approach in the treatment of lymphoma. This review article provides an overview of the four FDA-approved CAR T-cell products for aggressive B-cell lymphoma, including diffuse large B-cell ...
Bei Hu, Victoria Korsos, M. Lia Palomba, M. Lia Palomba   +3 more
doaj   +1 more source