Results 11 to 20 of about 14,561,710 (295)

Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma

Scientific Reports, 2021
T-cell non-Hodgkin’s lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin’s lymphoma to identify mutational ...
Christine L. Jones, Andrea Degasperi, Vieri Grandi, Tauanne D. Amarante, Genomics England Research Consortium, Tracey J. Mitchell, Serena Nik-Zainal, Sean J. Whittaker   +7 more
doaj   +2 more sources

Nivolumab-Associated Cardiac Manifestation of Cutaneous T-Cell Lymphoma in a Patient With Concurrent Renal Cell Carcinoma [PDF]

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Cardiac involvement by cutaneous T-cell lymphoma is exceedingly rare and poses considerable diagnostic and therapeutic challenges. Immune checkpoint inhibitors targeting programmed cell death-1 have reported variable activity in T-cell lymphomas and have
Mohamed Ibrahim, DO, Nitya Batra, MBBS, Oluwatayo Adeoye, MD, Michael Acevedo Monsanto, MD, Ephraim Parent, MD, PhD, David Li, MD, Muhamad Alhaj Moustafa, MD, MS   +6 more
doaj   +2 more sources

Cutaneous involvement in angioimmunoblastic T-cell lymphoma

Indian Journal of Dermatology, 2010
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive non-Hodgkin′s nodal peripheral T-cell lymphoma characterized by general lymphadenopathy, night sweats, fever, hepatosplenomegaly, polyclonal hypergammaglobulinemia, and cutaneous ...
Papadavid Evangelia, Panayiotides Ioannis, Dalamaga Marianna, Katoulis Alexandros, Economopoulos Theofanis, Stavrianeas Nikolaos   +5 more
doaj   +3 more sources

HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry

Acta Dermato-Venereologica, 2023
Differential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses.
Jingru Sun, Ran You, Beini Lyu, Xueying Li, Yumei Gao, Yujie Wen, Chenxue Qu, Yang Wang   +7 more
doaj   +1 more source

Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma

Nature Communications, 2022
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized.
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, P. Lai, De-Shu Xu, Jingru Sun, Zi-Yang Liu, Yu-Mei Gao, Yifan Zhao, Feng-Jie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bu-Fang Xu, Yuchieh Lin, M. Ran, Qianxi Li, Shu-Xia Yang, Hang Li, P. Tu, M. Haniffa, S. Teichmann, F. Bai, Yang Wang   +27 more
semanticscholar   +1 more source

Incidence Trends of Primary Cutaneous T-Cell Lymphoma in the US From 2000 to 2018

JAMA Oncology, 2022
Using SEER database data, this cohort study analyzed cutaneous T-cell lymphoma incidence by tumor subtype, sex, age, race and ethnicity, socioeconomic status, and geography.
Zhuo R. Cai, Michael L Chen, M. Weinstock, Youn H. Kim, R. Novoa, E. Linos   +5 more
semanticscholar   +1 more source

Randomized phase 3 ALCANZA study of brentuximab vedotin vs physician’s choice in cutaneous T-cell lymphoma: final data

Blood Advances, 2021
Key Points Final ALCANZA data confirm more durable responses and longer PFS with brentuximab vedotin vs control in CD30+ cutaneous T-cell lymphoma. Brentuximab vedotin extended the time to next treatment vs physician's choice, suggesting that durable ...
S. Horwitz, J. Scarisbrick, R. Dummer, S. Whittaker, M. Duvic, Youn H. Kim, P. Quaglino, P. Zinzani, Oliver Bechter, H. Eradat, L. Pinter-Brown, O. Akilov, L. Geskin, J. Sanches, P. Ortiz-Romero, M. Weichenthal, D. Fisher, J. Walewski, J. Trotman, Kerry Taylor, S. Dalle, R. Stadler, J. Lisano, V. Bunn, M. Little, H. Prince   +25 more
semanticscholar   +1 more source

High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma

Acta Dermato-Venereologica, 2021
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature T cells. However, in advanced stages, cutaneous T cell lymphoma may manifest aggressive clinical behaviour and lead to a poor prognosis.
Bufang Xu, Fengjie Liu, Yumei Gao, Jingru Sun, Yingyi Li, Yuchieh Lin, Xiangjun Liu, Yujie Wen, Shengguo Yi, Jingyang Dang, Ping Tu, Yang Wang   +11 more
doaj   +1 more source

Genetic and epigenetic insights into cutaneous T-cell lymphoma.

Blood, 2021
Primary cutaneous T-cell lymphomas (CTCL) constitute a heterogeneous group of non-Hodgkin T-cell lymphomas that present in the skin. In recent years significant progress has been made in the understanding of the pathogenesis of CTCL.
C. Tensen, K. Quint, M. Vermeer
semanticscholar   +1 more source

Use of Pegylated Interferon Alpha-2a in Cutaneous T-cell Lymphoma: A Retrospective Case Collection

Acta Dermato-Venereologica, 2023
Mycosis fungoides and Sézary syndrome are rare and largely incurable types of cutaneous T-cell lymphoma with limited therapeutic options. In 1984 Bunn et al.
Janika Gosmann, Rudolf Stadler, Koen D. Quint, Ralf Gutzmer, Maarten H. Vermeer   +4 more
doaj   +1 more source