Results 151 to 160 of about 465,548 (350)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients

Mediterranean Journal of Hematology and Infectious Diseases
We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosilate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zeste homolog 1 and 2, and subsequently bridged to ...
Gianmarco Bagnato, Vittorio Stefoni, Alessandro Broccoli, Lisa Argnani, Cinzia Pellegrini, Beatrice Casadei, Francesca Bonifazi, Pier Luigi Zinzani   +7 more
doaj   +1 more source

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial

The Lancet, 2019
S. Horwitz, O. O’Connor, B. Pro, T. Illidge, M. Fanale, R. Advani, N. Bartlett, J. Christensen, F. Morschhauser, E. Domingo-Domènech, G. Rossi, W. Kim, T. Feldman, A. Lennard, D. Belada, Á. Illés, K. Tobinai, K. Tsukasaki, S. Yeh, A. Shustov, A. Hüttmann, K. Savage, S. Yuen, S. Iyer, P. Zinzani, Zhaowei Hua, M. Little, Shangbang Rao, J. Woolery, T. Manley, L. Trümper, D. Aboulafia, O. Alpdogan, K. Ando, L. Arcaini, L. Baldini, Naresh Bellam, N. Bartlett, D. B. Yehuda, F. Benedetti, Peter Borchman, D. Bordessoule, P. Brice, J. Briones, D. Caballero, A. Carella, Hung Chang, June Weon Cheong, Seok-Goo Cho, I. Choi, S. Choquet, A. Colita, Angela Giovanna Congui, F. d'Amore, N. Dang, K. Davison, S. Guibert, P. Brown, V. Delwail, J. Demeter, F. Raimondo, Y. Do, E. Domingo, Michael G. Douvas, M. Dreyling, T. Ernst, K. Fay, S. Ferrero, I. Flinn, A. Forero-Torres, C. Fox, J. Friedberg, N. Fukuhara, J. García-Marco, Jorge Gayoso Cruz, J. Codina, R. Gressin, A. Grigg, R. Gurion, C. Haioun, R. Hájek, M. Hanel, K. Hatake, Rob Hensen, N. Horowitz, A. Huttmann, Á. Illés, K. Ishizawa, M. Islas‐Ohlmayer, E. Jacobsen, Murali Janakiram, W. Jurczak, M. Kaminski, Koji Kato, I. Kirgner, C. Kuo, M. Lazaroiu, K. Du, Jong-Seok Lee, S. Legouill, P. LaRosée, I. Levi, B. Link, H. Maisonneuve, D. Maruyama, J. Mayer, J. McCarty, P. McKay, Y. Minami, H. Mociková, E. Morra, J. Muñoz, H. Nagai, O. O'connor, Stephen Samuel Opat, R. Pettengell, A. Pezzutto, M. Pfreundschuh, A. Pluta, P. Porcu, H. Quach, A. Rambaldi, William E. P. Renwick, Ruben Reyes, A. Izquierdo, J. Ruan, C. Rusconi, G. Salles, A. Santoro, J. Sarriera, K. Savage, H. Shibayama, C. Suh, A. Sureda, M. Tanimoto, M. Taniwaki, H. Tilly, M. Trněný, L. Trumper, N. Tsukamoto, U. Vitolo, J. Walewski, E. Weidmann, M. Wilhelm, M. Witzens‐Harig, A. Yacoub, Kazuhito Yamamoto, S. Yoon, H. Yun, J. Zain   +149 more
semanticscholar   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Follicular T-cell lymphoma: A rare entity

Hematology Reports, 2020
Follicular T-cell lymphoma: A rare entity Background: Follicular T-cell lymphoma (FTCL) is a recently described variant of peripheral T-cell lymphoma, NOS in the World Health Organization (WHO) classifications of lymphoid neoplasms. It is a rare neoplasm
O.T. Eryilmaz, N. Dogruyol, A. Ozagari, F. Kabukcuoglu   +3 more
doaj  

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Unveiling the Enigma: Plasma Cell Leukaemia Presenting with Flower-like Cells, Mimicking Adult T-cell Leukaemia – A Rare Diagnostic Conundrum

Prague Medical Report
Peripheral plasma cell leukaemia (PCL) is a rare hematologic malignancy that can pose diagnostic challenges due to its resemblance to other conditions such as adult T-cell leukaemia/lymphoma (ATLL) or dissemination lymphoma in peripheral blood.
Anurag Singh, Gyanendra Singh
doaj   +1 more source

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source

Subcutaneous Panniculitis-like T-cell Lymphoma

Clinical Dermatology Review
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a primary, rare cutaneous T-cell lymphoma that resembles panniculitis and accounts for
Sonal Mandli, Rutu Harsh Oza, Amita H Sutaria, Bela J Shah   +3 more
doaj   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source