Therapeutic targeting of chromatin alterations in leukemia and solid tumors
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner+7 more
wiley +1 more source
Distribution reappraisal of peripheral T- and NK-cell lymphoma entities through the French Lymphopath network database. [PDF]
Grange T+20 more
europepmc +1 more source
Optimizing management of stage IV EGFR mutant non‐small cell lung cancer in Asia: An expert opinion
What's New? Emerging strategies for the treatment of advanced non‐small cell lung cancer (NSCLC) featuring epidermal growth factor receptor (EGFR) mutations are helping improve patient outcomes. Which strategies are optimal to effectively manage EGFR‐mutant NSCLC, however, remains unclear.
Gee‐Chen Chang+13 more
wiley +1 more source
Molecular analysis of bilateral T-cell vitreoretinal lymphoma. [PDF]
Soifer M+8 more
europepmc +1 more source
CD86, the double agent: Significance of CD86 expression in B‐cell malignancies
Abstract Bypassing the anti‐tumor functions of the immune system is one of the keys to tumor survival. Tumors, especially hematological tumors, produce or express factors that retune T and B cells to inhibit the immune response. Coreceptors CD28 and CTLA‐4, and their ligands, CD80 and CD86, are involved in the immunological synapse and play an ...
Gábor Barna+4 more
wiley +1 more source
High-Sensitivity Flow Cytometric Detection of a Small Circulating Population of Nodal T-Follicular Helper Cell Lymphoma Angioimmunoblastic Type Cells. [PDF]
Gatti A+8 more
europepmc +1 more source
Artificial intelligence in the diagnosis and management of gynecologic cancer
Abstract Gynecologic cancers affect over 1.2 million women globally each year. Early diagnosis and effective treatment are essential for improving patient outcomes, yet traditional diagnostic methods often encounter limitations, particularly in low‐resource settings.
Chaiyawut Paiboonborirak+2 more
wiley +1 more source
Novel Loop-Structure-Based CD19/CD22 Dual-Target CAR-T Therapy for High-Risk Diffuse Large B-Cell Lymphoma Presenting with Hemophagocytic Lymphohistiocytosis: A Case Report. [PDF]
Ye Y+8 more
europepmc +1 more source